Solid-state reactions of lanthanide(III) oxide (and lanthanide(III) oxyhalide), transition metal halide (and transition metal oxide), and TeO(2) at high temperature lead to six new lanthanide transition metal tellurium(IV) oxyhalides with three different types of structures, namely, DyCuTe(2)O(6)Cl, ErCuTe(2)O(6)Cl, ErCuTe(2)O(6)Br, Sm(2)Mn(Te(5)O(13))Cl(2), Dy(2)Cu(Te(5)O(13))Br(2), and Nd(4)Cu(TeO(3))(5)Cl(3). Compounds DyCuTe(2)O(6)Cl, ErCuTe(2)O(6)Cl, and ErCuTe(2)O(6)Br are isostructural. The lanthanide(III) ion is eight-coordinated by eight oxygen atoms, and the copper(II) ion is five-coordinated by four oxygens and a halide anion in a distorted square pyramidal geometry. The interconnection of Ln(III) and Cu(II) ions by bridging tellurite anions results in a three-dimensional (3D) network with tunnels along the a-axis; the halide anion and the lone-pair electrons of the tellurium(IV) ions are oriented toward the cavities of the tunnels. Compounds Sm(2)Mn(Te(5)O(13))Cl(2) and Dy(2)Cu(Te(5)O(13))Br(2) are isostructural. The lanthanide(III) ions are eight-coordinated by eight oxygens, and the divalent transition metal ion is octahedrally coordinated by six oxygens. Two types of polymeric tellurium(IV) oxide anions are formed: Te(3)O(8)(4)(-) and Te(4)O(10)(4)(-). The interconnection of the lanthanide(III) and divalent transition metal ions by the above two types of polymeric tellurium(IV) oxide anions leads to a 3D network with long, narrow-shaped tunnels along the b-axis. The halide anions remain isolated and are located at the above tunnels. Nd(4)Cu(TeO(3))(5)Cl(3) features a different structure. All five of the Nd(III) ions are eight-coordinated (NdO(8) for Nd(1), Nd(2), Nd(4), and Nd(5) and NdO(7)Cl for Nd(3)), and the copper(I) ion is tetrahedrally coordinated by four chloride anions. The interconnection of Nd(III) ions by bridging tellurite anions resulted in a 3D network with large tunnels along the b-axis. The CuCl(4) tetrahedra are interconnected into a 1D two-unit repeating (zweier) chain via corner-sharing. These 1D copper(I) chloride chains are inserted into the tunnels of the neodymium(III) tellurite via Nd-Cl-Cu bridges. Luminescent studies show that ErCuTe(2)O(6)Cl and Nd(4)Cu(TeO(3))(5)Cl(3) exhibit strong luminescence in the near-IR region. Magnetic measurements indicate the antiferromagnetic interactions between magnetic centers in these compounds.

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Structure D 2000 Luminescent Lanthanide Selenites and Tellurites Decorated by MoO 4 Tetrahedra or MoO6 Octahedra: Nd2MoSe2O10, Gd2MoSe3O12, La2MoTe3O12, and Nd2MoTe3O12. -Solid state reactions of Ln2O3 (Ln: Nd, Gd, La), MoO3, and SeO2 or TeO2 (evacuated quartz tube, 700-750°C, 6-7 d) lead to the four new quaternary title phases with four different types of structures. The structure of Nd2MoSe2O10 (triclinic, space group P1, Z = 2) features a three-dimensional architecture characterized by an intergrowth of Nd-Se-O and Nd-Mo-O layers. The structure of Gd2MoSe3O12 (triclinic, P1, Z = 2) consists a three-dimensional network of gadolinium selenite with cavities occupied by MoO6 octahedra. La2MoTe3O12 (orthorhombic, Pnma, Z = 4) exhibits a three-dimensional [La2(Te3O8) 2+ ] network with tunnels occupied by MoO4 tetrahedra. Nd 2 MoTe 3 O 12 (orthorhombic, Pnma, Z = 4) contains layers built by the Nd 3+ ions interconnected by tellurite and ditellurite groups, with the MoO4 tetrahedra as the interlayer pendant groups. Room temperature and low temperature luminescent studies indicate that the two Nd compounds exhibit strong luminescence in the near-IR region. -(SHEN, Y.-L.; JIANG, H.-L.; XU, J.; MAO*, J.-G.; CHEAH, K. W.; Inorg. Chem. 44 (2005) 25, 9314-9321; State Key Lab. Struct. Chem., Fujian Inst. Res. Struct. Matter, Chin. Acad. Sci., Fuzhou 350002, Peop. Rep. China; Eng.) -Schramke 09-008

This study aimed to elucidate the prognostic value of the leucine rich repeat containing 1 (LRRC1) gene in hepatocellular carcinoma (HCC) and to determine the effects of high and low LRRC1 expression on mutation and immune cell infiltration. We downloaded HCC mRNA-seq expression and clinical data from University of California Santa Cruz Xena. The expression of LRRC1 was compared between HCC tumor and normal samples. Tumor samples were divided according to high and low LRRC1 expression. Differentially expressed genes between the 2 groups were identified, and function, mutation, and immune cell infiltration were analyzed. Genes associated with immune cells were identified using weighted gene co-expression network analysis, and transcription factors of these genes were predicted. Moreover, a prognostic model was developed and its performance was evaluated. The expression of LRRC1 was upregulated in HCC tissues, and this indicated a poor prognosis for patients with HCC. Differentially expressed genes between high and low LRRC1 expression were significantly enriched in pathways associated with cancer, amino acid metabolism, carbohydrate metabolism, and the immune system. We identified 15 differentially infiltrated immune cells between tumors with high and low LRRC1 expression and 14 of them correlated with LRRC1 gene expression. Weighted gene co-expression network analysis identified 83 immune cell-related genes, 27 of which had prognostic value. Cyclic AMP-response element binding protein regulated annexin A5, matrix metallopeptidase 9, and LRRC1 in the transcription factor regulatory network. Finally, a prognostic model composed of 7 genes were generated, which could accurately predict the prognosis of HCC patients. The LRRC1 gene might serve as a potential immune-associated prognostic biomarker for HCC.

Key indicatorsSingle-crystal X-ray study T = 153 K Mean (C-C) = 0.015 Å R factor = 0.099 wR factor = 0.211 Data-to-parameter ratio = 13.5For details of how these key indicators were automatically derived from the article, see

Objective: This study aimed to elucidate the prognostic value of the leucine rich repeat containing 1 (LRRC1) gene in hepatocellular carcinoma (HCC) and to determine the effects of high and low LRRC1 expression on mutation and immune cell infiltration.Methods: We downloaded HCC mRNA-seq expression and clinical data from UCSC Xena. The expression of LRRC1 was compared between HCC tumor and normal samples. Tumor samples were divided according to high and low LRRC1 expression. Differentially expressed genes between the two groups were identified, and function, mutation, and immune cell infiltration were analyzed. Genes associated with immune cells were identified using weighted gene co-expression network analysis (WGCNA), and transcription factors (TFs) of these genes were predicted.Results: The expression of LRRC1 was upregulated in HCC tissues, and this indicated a poor prognosis for patients with HCC. Differentially expressed genes between tumors with high and low LRRC1 expression were significantly enriched in pathways associated with cancer, amino acid metabolism, carbohydrate metabolism, and the immune system. We identified 15 differentially infiltrated immune cells between tumors with high and low LRRC1 expression and 14 of them correlated with LRRC1 gene expression. We also identified 83 genes that were associated with immune cells. Cyclic AMP-response element binding protein (CREB1) regulated ANXA5, MMP9, and LRRC1 in the TF regulatory network.Conclusion: The LRRC1 gene might serve as a potential immune-associated prognostic biomarker for HCC.

Lanthanoids I 2800 Syntheses, Crystal Structures, and Properties of Six New Lanthanide(III) Transition Metal Tellurium(IV) Oxyhalides with Three Types of Structures. -Single crystals of the new compounds DyCuTe2O6Cl (I), ErCuTe2O6Cl (II), ErCuTe2O6Br (III), Sm2Mn(Te5O13)Cl2 (IV), Dy2Cu(Te5O13)Br2 (V), and Nd4(TeO3)5Cl3 (VI) are synthesized by solid state reactions of lanthanide oxide (and lanthanide oxyhalide), transition metal halide (and transition metal oxide), and TeO 2 at 700-750°C (6 d). As revealed by single crystal XRD, compounds (I-V) crystallize in the monoclinic space group P21/c with Z = 4 and compound (VI) in the monoclinic space group I2 with Z = 4. The compounds crystallize with three different types of structures. Compounds (II) and (VI) exhibit strong luminescence in the near-IR region. Magnetic measurements indicate antiferromagnetic interactions between magnetic centers in these compounds. -(SHEN, Y.-L.; MAO*, J.-G.; Inorg. Chem. 44 (2005) 15, 5328-5335; State Key Lab.