The activity of a nanozyme is closely related to its surface area-to-volume
ratio and the surrounding temperature. To acquire highly active nanozymes,
one-pot metallization-like synthesis of novel nanoflower-shaped photothermal
nanostructures was conducted using polyadenine-containing diblock
DNA as the scaffold. The nanoflower-shaped structures with a high
surface area-to-volume ratio and photothermal performance exhibited
excellent peroxidase-mimicking activity, and the biorecognition capability
was retained by the capping agent of diblock DNA. The functionalized
nanostructures were used for a proof-of-concept colorimetric assay
of cancer cells in vitro. Upon incorporation of 808 nm laser irradiation,
high sensitivity and selectivity for the cancer cell assay were achieved
with the lowest detection level of 10 cells/mL. Relative to spherical
gold nanostructures, the nanoflower-shaped photothermal nanozyme exhibited
higher assay sensitivity, paving the way for the construction of nanozyme-based
colorimetric sensors for point-of-care testing.
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