Objective: To explore the trend of detection and antimicrobial resistance of Serratia marcescens with different infection types for 7 consecutive years, to provide a reference for future studies for the control of S. marcescens infections and a rational selection of antibiotics.Methods: S. marcescens isolates were collected from 2014 to 2020, and the trend of detection and antimicrobial resistance were analyzed according to different types of infection.Results: For 7 consecutive years, the data showed that patients with S. marcescens infections were mainly from the intensive care unit (ICU) (384 isolates, 40.98%), and the isolates recovered were mainly from sputum samples (743 isolates, 79.30%). The number of isolated strains increased every year, and the average rate of detection ranged from 0.60% to 0.80%. The detection rate of S. marcescens with hospital-acquired infections (HAI) showed a downward trend and that of S. marcescens with colonization showed an upward trend. The detection rate of multidrug-resistant S. marcescens fluctuated between 8.33%–16.89%. The resistance rate of S. marcescens to piperacillin was 17.0%–29.06% and the resistance rate to piperacillin tazobactam was 2.95%–13.13%. For cephalosporin antibiotics, the resistance rates of S. marcescens to cefuroxime and cefazolin were >99% and the resistance rates to ceftazidime and cefepime were <13%. The resistance rate of S. marcescens to aminoglycoside antibiotics, especially amikacin, was the lowest. The resistance rate of S. marcescens with community-acquired infections (CAI) to carbapenems was higher than that with HAI and colonization.Conclusion: The different infection types of S. marcescens have different detection and epidemic trends. In addition, resistance to carbapenems is different across the strains.
Pulmonary hypertension(PH) is a common complication of chronic obstructive pulmonary disease(COPD) which can worsen the prognosis and increase the mortality of COPD patients. However, the underlying mechanisms of PH in COPD(COPD-PH) remain to be elucidated. This study is the first to explore the expression profile of circRNAs in human lung tissues with definite diagnosis of COPD-PH and validate the differentially expressed circRNAs(DECs) utilizing human serum, pulmonary arterial endothelial cells(HPAECs) and pulmonary arterial smooth muscle cells(HPASMCs). A total of 136 circRNAs(39 up-regulated and 97 down-regulated) were differentially expressed between the COPD-PH group and the control group. Following quantitative real-time polymerase chain reaction(qRT-PCR) validation, two circRNAs (hsa_circ_0007608 and hsa_circ_0064656) were believed to be involved in the pathogenesis. GO and KEGG pathway analysis suggested these two DECs were mainly related to the celluar proliferation, migration and EndoMT. PPI network revealed 11 pairs of key mRNAs. VCAM1, VCAN and THBS1, three hub mRNAs with the highest reliability among all, were validated and proven to be up-regulated in COPD-PH. We innovatively found that VCAN may be involved in COPD-PH. These identified genes show high potential to be diagnostic markers and therapeutic targets of COPD-PH, and may provide new insights into the underlying mechanisms of COPD-PH patients.
Background: Vitamin A supplementation has been advocated as a potential strategy to improve the vitamin A status of lactating mothers and infants. In China, vitamin A supplements are readily available in the form of daily oral low doses. However, the existing clinical trials are limited to single or two high-dose maternal administration.Objective: We aimed to evaluate the effects of the daily oral low-dose vitamin A supplementation on the retinol levels in serum and breast milk of lactating mothers and the health status of infants in China.Methods: Lactating mothers who met the inclusion criteria and planned to continue exclusive breast-feeding were randomly assigned to receive either daily oral vitamin A and D drops (one soft capsule of 1800IU vitamin A and 600IU vitamin D2), or a matching placebo for 2 months. Before and after the intervention, the dietary intake was investigated by instant photography, and the retinol concentration in maternal serum and breast milk was determined by UPLC. During the trial, the health status of infants was diagnosed by pediatrician or reported by lactating mothers.Results: 245 participants completed the study with 117 in supplementation group and 128 in control group. After the 2-month intervention, maternal serum retinol concentration increased in supplementation group with no change in control group. Although breast milk retinol concentrations decreased significantly in both groups, the decrease in supplementation group was significantly less than that in the control group. However, maternal vitamin A supplementation was not associated with lower risks of infant febrile illness, respiratory tract infection, diarrhea and eczema respectively. Conclusion: Daily oral low-dose vitamin A supplementation is helpful to improve the maternal vitamin A status and can also play a positive role in vitamin A status of infants through breast milk.
Objective To explore the trend of detection and antimicrobial resistance of Serratia marcescens with different infection types for 7 consecutive years, to provide a reference for future studies for the control of S. marcescens infections and a rational selection of antibiotics. Methods S. marcescens isolates were collected from 2014 to 2020, and the trend of detection and antimicrobial resistance were analyzed according to different types of infection. Results For 7 consecutive years, the data showed that patients with S. marcescens infections were mainly from the intensive care unit (ICU) (384 isolates, 40.98%), and the isolates recovered were mainly from sputum samples (743 isolates, 79.30%). The number of isolated strains increased every year, and the average rate of detection ranged from 0.60–0.80%. The detection rate of S. marcescens with hospital-acquired infections (HAI) showed a downward trend and that of S. marcescens with colonization showed an upward trend. The detection rate of multidrug-resistant S. marcescens fluctuated between 8.33–16.89%. The resistance rate of S. marcescens to piperacillin was 17.0–29.06% and the resistance rate to piperacillin tazobactam was 2.95–13.13%. For cephalosporin antibiotics, the resistance rates of S. marcescens to cefuroxime and cefazolin were > 99% and the resistance rates to ceftazidime and cefepime were < 13%. The resistance rate of S. marcescens to aminoglycoside antibiotics, especially amikacin, was the lowest. The resistance rate of S. marcescens with community-acquired infections (CAI) to carbapenems was higher than that with HAI and colonization. Conclusion The different infection types of S. marcescens have different detection and epidemic trends. In addition, resistance to carbapenems is different across the strains.
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