Health professionals should understand the mental health of parents with hospitalised neonates and take measures to reduce their psychological pressure so as to improve their care of the neonates, and help to maintain the harmony and stability of families and the whole society.
EA stimulation alleviates SNL-induced neuropathic pain, at least in part through inhibition of spinal glial activation. Moreover, inhibition of spinal microglia and astrocyte activation may contribute to the immediate effects and maintenance of EA analgesia, respectively.
BackgroundIn Western countries, a history of major depression (MD) is associated with reports of received parenting that is low in warmth and caring and high in control and authoritarianism. Does a similar pattern exist in women in China?MethodReceived parenting was assessed by a shortened version of the Parental Bonding Instrument (PBI) in two groups of Han Chinese women: 1970 clinically ascertained cases with recurrent MD and 2597 matched controls. MD was assessed at personal interview.ResultsFactor analysis of the PBI revealed three factors for both mothers and fathers: warmth, protectiveness, and authoritarianism. Lower warmth and protectiveness and higher authoritarianism from both mother and father were significantly associated with risk for recurrent MD. Parental warmth was positively correlated with parental protectiveness and negatively correlated with parental authoritarianism. When examined together, paternal warmth was more strongly associated with lowered risk for MD than maternal warmth. Furthermore, paternal protectiveness was negatively and maternal protectiveness positively associated with risk for MD.ConclusionsAlthough the structure of received parenting is very similar in China and Western countries, the association with MD is not. High parental protectiveness is generally pathogenic in Western countries but protective in China, especially when received from the father. Our results suggest that cultural factors impact on patterns of parenting and their association with MD.
The central mechanism of EA-induced anti-hyperalgesia may be partially associated with the reduced expression of p-p38 MAPK, and subsequently reducing the activation of OX-42 in neuropathic pain. Therefore, EA may be a new complementary and alternative therapy for neuropathic pain.
Electric vehicles (EVs) are expected to play a critical role in future transportation systems. A number of countries have published roadmaps aiming to facilitate the adoption of EVs on the road. It is estimated that existing charging facilities will not be able to satisfy the tremendous charging demands of a dramatically increasing number of EVs. Following the rapid development of artificial intelligence and mobile communication technology, certain charging pricing mechanism is expected to influence the charging behavior of EV drivers. In order to maximize the working efficiency of highway charging facilities and the consumption of the renewable energy near charging facilities, this paper proposes a pricing methodology taking into account the charging facility service ratio, traffic flow and renewable energy generation. To support the adoption of the proposed pricing methodology, forecasts of hour-by-hour traffic flow and renewable generation as well as calculation of the shortest paths to different charging stations (CSs) are investigated. A road network testbed based on the Dublin traffic network is established to evaluate the proposed pricing methodology. It is discovered that for certain wind-rich CSs, the proposed pricing methodology can increase the consumption rate of wind energy by up to 82.97%, with an average improvement of 30.73%; for certain solar-rich CSs, it can improve the level of solar energy consumption by up to 59.50% and an average increase of 29.28% is achieved. The proposed pricing methodology can also reduce traffic jams to some extent at both peak and off-peak times. INDEX TERMS Electric vehicle, charging stations, charging pricing methodology, renewable energy consumption. NOMENCLATURE
Interleukin-15 (IL-15) is a pleiotropic cytokine that plays a key role in the regulation of both innate and adaptive immune responses. It promotes the survival, proliferation, activation and maintenance of natural killer and CD8 + T cells. It also stimulates the function of neutrophils, macrophages and dendritic cells, and could therefore be a potential cytokine for cancer immune therapy. The therapeutic effects of cytokines are related to their expression levels. In this study, we investigated an amplified IL-15 expression plasmid vector, pHi2-spIL15-CMV-tat, and a carcinoembryonic antigen (CEA)positive tumor-specific amplified IL-15 expression plasmid vector, pHi2-spIL15-CEA-tat. In pHi2-spIL15-CMV-tat, IL-15 expression was driven by HIV2 LTR, which was transactivated by CMV promoter-controlled expression of HIV tat. In addition, the native IL-15 signal peptide was replaced by the IL-2 signal peptide to enhance its secretion. A significant amount of IL-15 expression was achieved when transfected into tumor cells in vitro. In order to target IL-15 expression in CEA-positive cells, the CEA promoter positively-controlled IL-15 expression plasmid vector pHi2-spIL15-CEA-tat was constructed by replacing the CMV with the CEA promoter. Efficient and targeted IL-15 expression was achieved in CEApositive tumor cells by pHi2-spIL15-CEA-tat.
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