No abstract

Using a single test to comprehensively evaluate multiple cardiac biomarkers for early diagnosis and prevention of acute myocardial infarction (AMI) has faced enormous challenges. Here, we have developed paper-based fluorogenic immunodevices for multiplexed detection of three cardiac biomarkers, namely, human heart-type fatty acid binding protein (FABP), cardiac troponin I (cTnI), and myoglobin, simultaneously. The detection is based on a strategy using zinc oxide nanowires (ZnO NWs) to enhance fluorescence signals (∼5-fold compared to that on pure paper). The immunodevices showed high sensitivity and selectivity for FABP, cTnI, and myoglobin with detection limits of 1.36 ng/mL, 1.00 ng/mL, and 2.38 ng/mL, respectively. Additionally, the paper-based immunoassay was rapid (∼5 min to complete the test) and portable (using a homemade chamber with a smartphone and an ultraviolet lamp). The developed devices integrated with ZnO NWs enable quantitative, sensitive, and simultaneous detection of multiple cardiac biomarkers in point-of-care settings, which provides a useful approach for monitoring AMI diseases and may be extended to other medical diagnostics and environmental assessments.

No abstract

To ensure wheel body of the hoisting sheave strength and stability condition. For the purpose of wheel body lightweighting. There are two schemes to reduce body weight.Reduce the spokes at the same time increase the ring stiffened plate, and reduce the spokes at the same time change the spokes width and thickness.The wheel body was established based on Pro/E 3D geometric model. Import the mesh in the Workbench of ANSYS software for finite element model. Statics analysis to select the optimized scheme. Establish a hoisting sheave wheel body under the actual working condition of widening the width -deformation -wheel weight relational table. Analysis to lightweight at the same time ensure that stiffness of wheel,then it can obtaine the optimal result.