Postoperative cognitive dysfunction (POCD), commonly observed in elderly patients, is characterized by impaired concentration, memory and learning following surgery, and may persist for a long duration or progress into serious central nervous system diseases. It has been demonstrated neuroinflammation caused by surgery is involved in the development of POCD. However, the detailed molecular mechanism remains to be fully elucidated. The present study aimed to reveal the role of tumor necrosis factor (TNF)-α in the development of POCD in aged rats. Laparotomy was performed to mimic human abdominal surgery in the aged rats. Following surgery, the memory and learning functions were impaired, with significant upregulation of pro-inflammatory cytokines, including TNF-α, interleukin (IL)-1β, IL-4 and IL-6 in the hippocampal tissues. However, intracisternal administration of the TNF-α receptor antagonist, R-7050, during surgery attenuated these defects in cognitive function and inhibited the production of the pro-inflammatory cytokines in the hippocampal tissues. Furthermore, intracisternal administration of R-7050 inhibited the activation of the downstream nuclear factor-κB and mitogen-activated protein kinase signaling pathway in the hippocampal tissues. Therefore, the results of the present study suggested a key role of the TNF-α-mediated signaling pathway in the development of POCD.
Correlation of xeroderma pigmentosum complementation group F (XPF) expression with gastric cancer and prognosis was investigated. We randomly selected 76 gastric cancer patients who were admitted to the Second People's Hospital of Dezhou City and received treatment, and detected XPF expression in gastric cancer tissues (observation group) and normal gastric mucosa adjacent to tumor (control group) via immunohistochemistry. Correlation between XPF expression and clinicopathological indicators of gastric cancer was verified via single-factor Chi-square test. Cox's proportional hazard regression model was used in the analysis of influencing factors of patient's prognosis, and Kaplan-Meier was used to analyze the survival rates of XPF-positive and -negative patients. In the observation group, the XPF-positive rate was significantly higher than that in the control group with a statistically significant difference (P<0.05). Single-factor analysis showed that XPF expression was correlated with the family history and Laurén classification (P<0.05). Kaplan-Meier survival analysis revealed that the survival time of XPF-positive patients was shorter than that of XPF-negative patients (P<0.05). Multifactorial analysis using Cox's hazards model suggested that XPF was an independent factor affecting the prognosis of gastric cancer (P<0.05). In conclusion, XPF expression plays an important role in the occurrence and development of gastric cancer, and a high expression of XPF suggests a poor prognosis of gastric cancer patients.
The composite conductive copolymers of polyaniline/polythiophene (Pani/PTH) were successfully prepared by an electrochemical method on a stainless steel surface containing both aniline and thiophene in a 0.3[Formula: see text]mol/L oxalic acid solution. The anti-corrosion performance of the Pani/PTH on stainless steel surfaces was investigated in acidic media by polarization curve analysis and electrochemical impedance spectroscopy (EIS). Additionally, the surface morphology of Pani/PTH composite conductive copolymers was observed by scanning electron microscopy (SEM). The results showed that the Pani/PTH copolymers strongly adhered to the surface of the stainless steel. Compared with that of bare stainless steel, composite conductive copolymers of Pani/PTH on the stainless steel surface provided good anti-corrosion behavior; additionally, the corrosion potential could be improved by approximately 400[Formula: see text]mV, while the current density decreased by two orders of magnitude in the corrosion media. The above results were in accordance with the SEM characterization results. The SEM spectrum showed that the Pani/PTH film had a uniform, dense and shiny structure, so it had better anti-corrosion behavior.
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