A family history of dementia is associated with an increased risk of developing Alzheimer’s disease (AD) late in life (LOAD). This study marked the first attempt to assess the familial contribution to differences in cognitive performance in a large family-based group in the Chinese community. We enrolled 168 participants without dementia from a single pedigree with 9 probable AD patients diagnosed after age 65. These participants were evaluated with a comprehensive neuropsychological battery, the Chinese version of the Mini Mental State Examination, and the Alzheimer Disease Assessment Scale–Cognitive Subscale. Analyses found that extended family members of the LOAD pedigree showed similar performance on measures of global cognitive function and semantic memory compared to controls, but lower scores on episodic memory, attention, and executive function measures. These results indicate that the genetic influences on certain sub-cognitive domains are more detectable despite normal global cognitive function, and that family members with the LOAD pedigree are at risk for developing LOAD by virtue of their family history with an additive risk due to increased age. The findings in this study support the importance of documenting if there is a positive family history of AD in clinical evaluations.

Existing motion capture technology can efficiently track whole-body motion and be applied to many areas of the body. This whole-body interaction design has gained the attention of many researchers. However, few scholars have studied its suitability for elderly users. We were interested in exercise-based whole-body interactive games, which can provide mental and physical exercise for elderly users. We used heuristic evaluation to measure participants’ actions during exergame tasks and analyzed preference differences between elderly and younger users through the distribution of actions in four dimensions. We found that age affected the actions performed by users in exergame tasks. We discuss the mental model of elderly users during the process of performing these tasks and put forward some suggestions for interactive actions. This model and these suggestions theoretically have guiding significance for the research and application of exergame design for elderly users and may help designers develop more effective exergames or other whole-body interaction interfaces suitable for elderly users.

In this paper, super-gravity solidification and cold-rolling were utilized to obtain Al-14.5Si alloys. The influence of annealing time on microstructure and mechanical properties of Al-14.5Si alloys was investigated. Our results indicated that high elongation was achieved by super-gravity solidification due to the submicron eutectic Si, making it possible to undertake the conventional cold-rolling. The yield strength (~214 ± 11 MPa) was significantly enhanced (~68.5%) after cold-rolling mainly due to high dislocation density. The coarsening of eutectic Si could be observed during annealing, which resulted in a decrease in yield strength. The elimination of internal stress and lattice distortion during annealing led to a decrease in micro-cracks/voids beneath the fracture surface during tensile testing, which in turn enhanced the elongation.

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