There are currently no effective biomarkers for diagnosing Parkinson’s disease (PD) or tracking its progression. Here, we developed an artificial intelligence (AI) model to detect PD and track its progression from nocturnal breathing signals. The model was evaluated on a large dataset comprising 7,671 individuals, using data from several hospitals in the United States, as well as multiple public datasets. The AI model can detect PD with an area-under-the-curve of 0.90 and 0.85 on held-out and external test sets, respectively. The AI model can also estimate PD severity and progression in accordance with the Movement Disorder Society Unified Parkinson’s Disease Rating Scale (R = 0.94, P = 3.6 × 10–25). The AI model uses an attention layer that allows for interpreting its predictions with respect to sleep and electroencephalogram. Moreover, the model can assess PD in the home setting in a touchless manner, by extracting breathing from radio waves that bounce off a person’s body during sleep. Our study demonstrates the feasibility of objective, noninvasive, at-home assessment of PD, and also provides initial evidence that this AI model may be useful for risk assessment before clinical diagnosis.

In this paper, we investigate a weakly-supervised object detection framework. Most existing frameworks focus on using static images to learn object detectors. However, these detectors often fail to generalize to videos because of the existing domain shift. Therefore, we investigate learning these detectors directly from boring videos of daily activities. Instead of using bounding boxes, we explore the use of action descriptions as supervision since they are relatively easy to gather. A common issue, however, is that objects of interest that are not involved in human actions are often absent in global action descriptions known as "missing label". To tackle this problem, we propose a novel temporal dynamic graph Long Short-Term Memory network (TD-Graph LSTM). TD-Graph LSTM enables global temporal reasoning by constructing a dynamic graph that is based on temporal correlations of object proposals and spans the entire video. The missing label issue for each individual frame can thus be significantly alleviated by transferring knowledge across correlated objects proposals in the whole video. Extensive evaluations on a large-scale daily-life action dataset (i.e., Charades) demonstrates the superiority of our proposed method. We also release object bounding-box annotations for more than 5,000 frames in Charades. We believe this annotated data can also benefit other research on video-based object recognition in the future.

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