2′-5′-oligoadenylate synthetases (OAS) family is interferon (IFN) -induced antiviral enzymes including OAS1, OAS2, OAS3, and OAS-like (OASL) is increasingly thought to play significant roles in human cancers. This study aims to explore the potential role of OAS family genes with a new clue to providing insights on tumor immune mechanisms implicated here. High expression levels of OAS family gene were observed in most cancer types. OAS family gene expression in tumor samples correlated with poor overall survival in several cancers such as Brain Lower Grade Glioma (LGG). OAS family genes were associated with M1 macrophages in cancers. Tumor mutation burden (TMB), microsatellite instability (MSI) correlated with OAS family genes dysregulation in cancers. OAS1/OAS3/OASL is a promising target for AP-26113, and OAS2/OASL is more likely to be an effective target for itraconazole. OAS1 and OASL were significantly correlated with their pathological stages in KIRC. OAS family genes were positively correlated with M1 macrophages. Gene set enrichment analysis (GSEA ) results demonstrated OAS1/OAS2/OASL have pathways commonly associated with immunity in KIRC such as natural killer cell mediated cytotoxicity. Our study suggests that OAS family genes may influence cancer development, particularly KIRC, by modulating M1 macrophages and NK cells.
By means of questionnaire and quantitative research, this article aims at investigating the effects on students' mastery of vocabulary by studying teachers' adoption of seven kinds of common vocabulary teaching strategies and the usage of analyzing strategies in intensive English in order to improve vocabulary teaching strategies and to help enlarge students' vocabulary.
Abstract. Colleges and universities have the important responsibility of cultivating all kinds of high quality talents and leaders for the society. At present, many colleges and universities are exploring the different mode and way of Cultivating College Students' leadership. We find that the Students' leadership training still exist many problems based on the literature research, questionnaire survey; Combined with the teaching practice, the connotation of leadership research, the orientation of training ideas, we need to improve the training system, optimize the training process and the construction of evaluation system, and promote the improvement of College Students' leadership.
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