Increased expression of GP73 promotes proliferation and migration of HCC cell lines and growth of xenograft tumors in mice. mTORC1 regulates the expression of GP73, so GP73 up-regulation can be blocked with rapamycin. mTOR inhibitors or other reagents that reduce the level or activity of GP73 might be developed for the treatment of HCC.

A series of bio-adsorbents with potential for Pb(II) removal from wastewater were prepared by treating Radix Isatidis residue (RIR) with integrated chemical treatment and fermentation methods. Batch experiments were used to test the adsorption and desorption performance of different bio-adsorbents. The results showed that treated RIRs had significantly enhanced adsorption capacity of 23.5 and 27.6 mg g−1 for Pb(II) within 50 minutes, in contrast to the raw RIR's 12.2 mg g−1. RIR produced by modified chemical/fermentation treatment can remove up to 31.1 mg g−1. After five adsorption/desorption cycles, about 75% of the adsorption capacities was maintained. This study is a novel approach to reusing the enormous quantity of Chinese herbal medicine residues.

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