The resulTs of The acuTe ToxiciTy sTudies of "dolosan forTe ® " TableTs This study aimed to evaluate the parameters of acute toxicity of the new combined tablets "Dolosan Forte ® " (containing zirilon-2,4-dichlorobenzoic acid potassium salt, pitofenone hydrochloride, fenpiverinium bromide) worked out by PJSC "Red Star". It has been shown that LD 50 for these tablets administered intragastrically equals 13231 ± 2775 mg/kg in male rats, 13216 ± 3379 mg/kg in female rats, 14393 ± 1669 mg/kg in male mice and 11963 ± 2023 mg/kg in female mice, corresponding to the V class of practically nontoxic substances (5000 mg/kg < LD 50 < 15000 mg/kg). The death of the rats and mice receiving the investigated tablets can be possibly caused by the neurotoxic action of the drug with the rapid development of convulsions. The survived animals demonstrated normal state during 14 days. Macroscopic examination showed the absence of the morphological signs of the toxic effect of "Dolosan Forte ® " tablets on the visceral systems of the survived rats and mice (except for the increment of the relative organ weights in the groups of animals receiving doses causing high lethality rate). Microscopic investigation did not reveal any pathological changes of the internal organs of rats after the single intragastric administration of "Dolosan Forte ® " tablets at a dose of 6000 mg/kg. There were no interspecies as well as sex-specific differences in "Dolosan Forte ® " toxic effects. The obtained results together with the data in the literature concerning LD 50 for the components of "Dolosan Forte ® " show that combined use of zirilon (2,4-dichlorobenzoic acid potassium salt), pitofenone hydrochloride, fenpiverinium bromide does not cause the increase in their acute toxicity.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
customersupport@researchsolutions.com
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.