Amorphous polymers with ultralong room‐temperature phosphorescence (RTP) are highly promising for various applications. Particularly, polymer‐based RTP materials with multiple functions such as color‐tunability or stimulus‐response are highly desirable for multilevel anti‐counterfeiting but are rarely reported. Herein, a facile strategy is presented to achieve a series of polymer‐based RTP materials with ultralong lifetime, multicolor afterglow, and reversible response to UV irradiation by simply embedding pyridine‐substituted triphenylamine derivatives into the polymer matrix poly(vinyl alcohol) (PVA) and poly(methyl methacrylate) (PMMA), respectively. Notably, the pyridine group with the capabilities of promoting intersystem crossing and forming hydrogen‐bonding interactions is essential for triggering ultralong RTP from the doping PVA system, among which the doping film TPA‐2Py@PVA exhibits excellent RTP property with an ultralong lifetime of 798.4 ms and a high quantum yield of 15.2%. By further co‐doping with the commercially available fluorescent dye, multicolor afterglow is obtained via phosphorescence energy transfer. Meanwhile, the doped PMMA system exhibits reversible photoactivated ultralong RTP properties under continuous UV irradiation. Finally, potential applications of these doped PVA and PMMA systems with ultralong lifetime, multicolor afterglow, and photoactivated ultralong RTP in multidimensional anti‐counterfeiting are demonstrated.
Kidney transplantation is the gold standard for the treatment of end-stage renal disease (ESRD). However, the scarcity of kidneys has caused more and more ESRD patients being stuck on the waiting-list for surgery. Improving the survival rate of kidney grafts as much as possible is not only responsible for patients, but also an alternative solution to kidney shortage. Thus, rapid diagnosis and timely management of surgical complications are of vital importance to the success of renal transplantation but lack efficient methods and technologies. Herein, a fluorescence technology based on bright, photostable, and long-circulating aggregation-induced emission (AIE) active NIR-II nano contrast agent for the whole-process monitoring and evaluation of renal transplantation has been reported. The outstanding optical property and long-circulating characteristic of the AIE NPs help to achieve renal angiography in the kidney retrieval surgery, donor kidney quality evaluation before transplantation, diagnosing vascular complications, and assessment of renal graft reperfusion after revascularization, which considerably outperforms the clinically approved indocyanine green (ICG).
Targeted and controllable drug release at lesion sites with the aid of visual navigation in real-time is of great significance for precise theranostics of cancers. Benefiting from the marvellous features (e.g. bright emission and phototheranostic effect in aggregates) of aggregation-induced emission (AIE) materials, constructing AIE-based multifunctional nanocarriers that act as all-rounders to integrate multimodalities for precise theranostics is highly desirable. Here, an intelligent nanoplatform (P-TN-Dox@CM) with homologous targeting, controllable drug release, and in vivo dual-modal imaging for precise chemo-photothermal synergistic therapy is proposed. AIE photothermic agent (TN) and anticancer drug (Dox) are encapsulated in thermo-/pH-responsive nanogels (PNA), and the tumor cell membranes are camouflaged onto the surface of nanogels. Active targeting can be realized through homologous effects derived from source tumor cell membranes, which significantly elevates the specific drug delivery to tumor sites. After being engulfed into tumor cells, the nanogels exhibit a burst drug release at low pH. The near-infrared (NIR)-photoinduced local hyperthermia can activate severe cytotoxicity and further accelerate drug release, thus generating enhanced synergistic chemo-photothermal therapy to thoroughly eradicate tumors. Moreover, P-TN-Dox@CM nanogels could achieve NIR-fluorescence/photothermal dual-modal imaging to monitor dynamic distribution of therapeutics in real-time. This work highlights the great potential of smart P-TN-Dox@CM nanogels as a versatile nanoplatform to integrate multimodalities for precise chemo-photothermal synergistic therapy in combating cancers.
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