1 Twenty-one hypertensive patients unable to tolerate P-blockade were treated with indoramin (50-150 mg) and a diuretic (mainly bendrofluazide 5 mg) on an open basis over a period of between 6 and 25 months. 2 With a twice daily dosage of indoramin blood pressure was adequately controlled in 80% of patients after six months of treatment and nearly 90% after one year of treatment. Pulse rate dropped slightly after the first month of treatment but remained steady thereafter. The mean dose of indoramin required for control of blood pressure was 80 mg per day. 3 There was a significant increase in weight in the first few months of treatment but this was considered to be unrelated to indoramin treatment. 4 Drowsiness was the commonest side-effect but only one patient withdrew from the study for this reason. Dosage reduction or taking a larger evening dose after food alleviated this symptom. One patient each was withdrawn for vertigo and headaches. 5 Indoramin is considered to be an acceptable and effective alternative treatment for hypertension in patients unable to tolerate 1-blockers.
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