Asymmetrically substituted 5,10,15,20-tetraphenylporphyrin derivatives such as
5-(4-aminophenyl)10,15,20-triphenylporphine,
5-[4-(tyrosinylamino)phenyl]-10,15,20-triphenylporphine and 5-{4-[(
N
-
tert
-butoxycarbonyltyrosinyl)amino]phenyl}-10,15,20-triphenylporphine
were synthesized. Their spectral and acid-base properties were studied. The
acid-base interactions of the obtained compounds in the binary
acetonitrile–perchloric acid and dimethyl sulfoxide–potassium cryptate
(KOH[222]) systems were studied by spectrophotometry method. The effect of the
nature of the solvent, concentration, pH value on the chemical activity of
porphyrin was analyzed. Amino acid fragments affect the protolytic equilibrium
of porphyrins in acidic and basic media.
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