[1] Discrete scarps that are created or reactivated during large earthquakes are a locus of concentrated hazard. A number of the coseismic scarps activated in the 1999 Chi-Chi earthquake are actually fold scarps, which display several types of ground deformation characterized by localized folding and are distinct from classic fault scarps, which form by a fault cutting the surface. This paper documents and analyzes fold scarps that formed or reactivated in the 1999 Chi-Chi Taiwan earthquake. Our results show the Chi-Chi fold scarps can be generally divided into two types: (1) those associated with folding ahead of the tip of a blind thrust fault at shallow depths and (2) those associated with folding by kink band migration above fault bends at substantial depths ranging from $0.8 to 5 km). The previously published trishear model can be applied to model the former type, while a new curved hinge kink band migration model is provided to describe the behavior of the latter type. A key feature of fold scarps of the second type is that hinge zones are typically wide (25-100 m) relative to the displacement in a single earthquake (1-10 m), which exerts a significant control on fold scarp morphology and evolution. Because the coseismic strains of both types of fold scarps display relatively wide deformation zones (10-100 m) relative to fault scarps, wider set-back zones might be appropriate from a public policy point of view to alleviate the risk to structural damage and collapse resulting from permanent ground deformation.
A drug delivery system of quercetin (QU)-encapsulated liposomes (LS) grafted with RMP-7, a bradykinin analog, and lactoferrin (Lf) was developed to permeate the blood–brain barrier (BBB) and rescue degenerated neurons, acting as an Alzheimer’s disease (AD) pharmacotherapy. This colloidal formulation of QU-encapsulated LS grafted with RMP-7 and Lf (RMP-7-Lf-QU-LS) was used to traverse human brain microvascular endothelial cells (HBMECs) regulated by human astrocytes (HAs) and to treat SK-N-MC cells after an insult with cytotoxic β-amyloid (Aβ) fibrils. We found that surface RMP-7 and Lf enhanced the ability of QU to cross the BBB without inducing strong toxicity and damaging the tight junction. In addition, RMP-7-Lf-QU-LS significantly reduced Aβ-induced neurotoxicity and improved the viability of SK-N-MC cells. Compared with free QU, RMP-7-Lf-QU-LS could also significantly inhibit the expression of phosphorylated c-Jun N terminal kinase, phosphorylated p38, and phosphorylated tau protein at serine 202 by SK-N-MC cells, indicating an important role of RMP-7, Lf, and LS in protecting neurons against apoptosis. RMP-7-Lf-QU-LS is a promising carrier targeting the BBB to prevent Aβ-insulted neurodegeneration and may have potential in managing AD in future clinical applications.
Rapid exhumation of 3–10 mm/yr of the Taiwan metamorphic range is often explained as the unroofing of the retrowedge of a doubly vergent mountain belt. Yet, to date, the Central Range fault forming the boundary of the retrowedge has displayed no definitive evidence for recent seismic activity and no unambiguous geomorphic expression over much of the fault. The 2013 M6.4 Rueisuei reverse‐faulting earthquake nucleated at the eastern boundary of the retrowedge and appears to illuminate the west dipping Central Range fault. We estimate the fault geometry and coseismic slip distribution using a uniform stress drop slip inversion and surface displacements derived from GPS and strong‐motion data. We identify a ~42° dipping blind reverse fault, consistent with the previously proposed buried Central Range fault beneath the highly active Longitudinal Valley fault. This earthquake may be the first indication that rapid exhumation and uplift occur along a distinct fault structure bounding the eastern margin of the Taiwan retrowedge.
S U M M A R YNorthern Taiwan underwent mountain building in the early stage of the Taiwan orogeny but is currently subjected to post-collisional crustal extension. It may be related to gravitational collapse or to the rifting of the Okinawa Trough, which lies offshore northeastern Taiwan. The Ilan Plain, northeastern Taiwan, which is bounded by the normal fault systems and filled up with thick Pliocene-Pleistocene sedimentary sequences, formed under such an extension environment. Over there on 2005 March 5 two earthquakes with about the same magnitude (M L = 5.9) occurred within 68 s and produced intense aftershocks activity according to the records of Central Weather Bureau Seismic Network of Taiwan. We relocated the earthquake sequence by the three-dimension earthquake location algorithm with the newly published 3-D Vp and Vp/Vs velocity model, and determined the first-polarity focal mechanisms of the earthquake doublet. One major cluster of aftershocks which trends E-W and dips steeply to the south can be identified and picked up as a potential fault plane. The focal mechanisms of the two main shocks are both classified as normal type by first-polarity but strike-slip by centroid moment tensor inversion; however two methods both yield consistent E-W strike. Static coseismic deformation was additionally determined from Global Positioning System (GPS) daily solutions at a set of continuous GPS stations and from strong-motion seismographs. These data show NW-SE extension at high angle to the fault plane, which cannot be explained from a simple strike-slip double-couple mechanism. On the other hand, the small vertical displacements and steep fault plane cannot be explained from a simple normal event as well. We present from elastic dislocation modelling that the geodetic data are best explained by significant component of tensile source with centimetre-scale of opening on a 15-km-long fault extending from 1 to 13 km depth. We therefore interpret the crisis as the result of dyke intrusion at the very tip of the Okinawa Trough, which is reasonably driven by backarc spreading.
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