A series of mono-and biquaternized derivatives of dipyridylethanes and dipyridylethylenes has been synthesized and characterized with respect to antimicrobial activity. The new compounds exhibit structure-dependent antimicrobial action on both Gram-negative (E. coli) and Gram-positive (St. aureus) bacterial species. Monoquaternized dipyridylethane and dipyridylethylene derivatives show a higher antimicrobial activity than compounds with two onium nitrogen atoms; derivatives of dipyridylethane are less active than the analogous derivatives of dipyridylethylene. A high antimicrobial activity (MIC~1 mg/ml) was observed for 1-[N-cetyl-(4-pyridinium)]-2-(4-pyridyl)ethylene.
1940091-150X/06/4004-0194
A series of mono-and biquaternized derivatives of dipyridylethane and dipyridylethylenes were synthesized in order to study their antimicrobial activity (AMA) with respect to Gram-negative (E. coli) and Gram-positive (S. aureus) species. It is established that the antimicrobial activity depends on the nature of the radical on the nitrogen atom, the positions of the ethane and ethylene bridges between the rings relative to the onium nitrogen atoms, and the presence of conjugated systems between these atoms. The maximum AMA with respect to the indicated test microbe strains was observed for 1-(N-dodecylpyridin-4-yl)-2-(4-pyridyl)ethylene bromide (MIC 3.9 and 2.0 mg/mL, respectively).
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