A copper-catalyzed aerobic decarboxylative sulfonylation of alkenyl carboxylic acids with sodium sulfinates is developed. This study offers a new and expedient strategy for stereoselective synthesis of (E)-alkenyl sulfones that are widely present in biologically active natural products and therapeutic agents. Moreover, the transformation is proposed to proceed via a radical process and exhibits a broad substrate scope and good functional group tolerance.
Fluorinated compounds have found widespread applications
in pharmaceuticals,
agrochemicals, and materials science. Precise construction of α-difluoromethylene
ether (CF2
–O) moiety in organic molecules
is of high demand. Herein, a visible light-promoted reaction protocol
for the synthesis of α-difluoromethylene ether from gem-difluorocyclopropane is described. The key ring-opening
step is induced by hyperconjugative interaction of cyclopropane with
photo-oxidized aromatic rings. This reaction is easy scale-up, and
the products bearing a synthetic handle enable their further manipulation.
Formaldehyde (CH2O) has been used as a key platform reagent in the chemical industry for many decades. In the current stage, the industrial production of CH2O mainly depends on the...
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