It has been established that convolvine blocks the M-receptors of the heart and intestine but ra&es the sensitivity of the M-receptors of the salivary gland and of the CNS, while atropine blocks all the abovementioned M-receptors. Convolvine has revealed characteristics of a sedative and nootropic agent. Atropine, however, which is known as a psychomotor stimulator, prevents the realization of a conditioned gastromotor reflex. An analysis has been made of the relationship between features of the pharmacological activities and chemical structures of convolvine and atropine.Plants of the genus Convolvulus (bindweed) were first studied by A. P. Orekhov, R. A. Konovalova [1], and S. Yu. Yunusov. From C. pseudocantabrica and C. subhirsutus they isolated the two alkaloids convolvine and convolamine and established their structures. They were the first to show the presence of tropane alkaloids in plants of the Convolvulaceae family. S. Yu. Yunusov and coworkers determined the maximum amounts of the total alkaloids in the epigeal parts of the plants --2.08% --and in the roots --4.1% [2].The main alkaloid of both species is convolvine, making up about 1% of the air-dry weight of the raw material. Convolvine (1) is an ester of the amino alcohol nortropine and 3,4-dimethoxybenzoic (veratric) acid and belongs to the class of tropane alkaloids, like atropine (2), which is an ester of the amino alcohol tropine and dl-tropic acid. Atropine is one of the standard M-cholinoblockers. With the aim of evaluating the neuro-and psychotropic activities of convolvine and also to elucidate the relationship between structural features and biological activity we have made a comparative study of convolvine and atropine in those directions where the pharmacological properties of the latter are generally known.
The reductive alkylation of cytisine by various aromatic aldehydes was studied. Preliminary pharmacological investigations of the synthesized compounds were performed.
At the Yunusov Institute of Plant Chemistry of the Academy of Sciences of the Republic of Uzbekistan, a number of scientists conducted extensive pharmaco-toxicological studies to study the biological activity of vincane hydrochloride and its derivatives. Based on these studies, a number of studies were conducted not only on the special pharmacological activity of the substances studied, but also on their effects on organs and systems, including respiration and blood pressure. Based on the conducted studies, it was found that in acute experiments on cats, vincanin hydrochloride and derivatives in doses of 0.3 – 5.0 showed a tendency to increase blood pressure and somewhat increased breathing. However, at higher doses, tonic clonic seizures occurred, leading to the death of experimental animals. This requires the use of these substances in very small doses, as far as possible, in order to achieve a therapeutic effect. In studies of changes in the body weight of experimental animals in dynamics, vincanin hydrochloride and pyrosaline chloride did not have a negative effect on the ratio between the control group, although they slightly changed the weight of animals, while pyrosaline iodomethylate did not have a negative effect on the change in body weight of experimental animals in dynamics compared with vincanin hydrochloride and pyrosaline chloride.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.