Objective: To investigate the role of programmed death-1 (PD-1), programmed death-ligand 1 (PD-L1), and P16 in patients with head and neck squamous cell carcinoma (HNSCC). Methods: A total of 95 paraffin-embedded samples of tumorous tissue of HNSCC were collected. Expression levels of PD-1, PD-L1, and P16 were determined by immunohistochemistry. Results: A significantly higher proportion of PD-1 among patients infected with the human papillomavirus was found. PD-L1 expression is closely associated with the primary site of the tumor, postoperative recurrence, survival, PD-1 expression and P16 expression. Univariable analysis indicated that T stage, N stage, tumor node metastasis stage, tumor differentiation, and PD-L1 expression were all shown to be prognostic variables for overall survival in patients with HNSCC. In the multivariate analysis, only N stage ( P = 0.010) and PD-L1 expression ( P = 0.001) were found to be independent prognostic variables for overall survival. In addition, for disease recurrence, multivariate analysis showed that only PD-L1 expression was the associated independent risk factor. For the patients with negative PD-L1 expression, Kaplan-Meier analysis revealed that they had significantly worse outcomes in terms of overall survival ( P = 0.001). Similarly, compared with the patients with positive PD-L1 expression, those with negative PD-L1 expression had a higher probability of recurrence ( P = 0.026). Conclusions: The expression of PD-L1, PD-1, and P16 in HNSCC is significantly correlated. Human papillomavirus infection (P16 positive) is negatively related to postoperative recurrence. HNSCC patients with positive PD-L1/PD-1 expression tend to have better overall survival outcomes and lower probability of recurrence, providing more evidence for the PD-l-targeted immunotherapy of HNSCC.
In this paper, the modulated transmission property of bacteriorhodopsin (bR) film is analyzed theoretically when two beams of light, yellow light and purple light, illuminate the b R film simultaneously. B y using the transmission property of bR film, the winner-take-all thresholding operation can be realized.
In this study, c-axis oriented AlN and Al1−xScxN films have been successfully grown on Si (100) and quartz glass by DC magnetron reactive sputtering method. The XRD patterns show that the crystal structure of the Al1−xScxN films is (002) orientation. The grain size and band gap energy (Eg) of the Al1−xScxN films decrease as the Sc concentration increases. The frequency of the E2 (high) mode observed in the Al1−xScxN films shows higher red shift compared to that observed in AlN film and the peak shifts to the low wave number with the increasing of Sc concentration.
Two current signal injection methods, the fluctuating high frequency (HF) current signal injection and low frequency (LF) current signal injection, were discussed. The basic principles of rotor position self-sensing using these current signal injection and the key techniques in implementation were presented and the simulation models for sensorless vector control systems of a permanent magnet synchronous motor (PMSM) were established using two proposed rotor position estimation methods. Comparative simulation study of the fluctuating HF current signal injection and LF current signal injection was investigated, and draw the conclusions that the saliency-tracking scheme using fluctuating HF current signal injection possesses simpler configuration and better speed-adjustable performance both in static and dynamic.
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