Declaration of interest:Role of the funding source: This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.Author contributions: YHL designed the study. YHL and CHL conducted the study and analyzed the data. YHL and YCC drafted the manuscript. All authors contributed to data analysis, drafting or revising the article, gave final approval of the version to be published, and agree to be accountable for all aspects of the work. Highlights The increased Google searches for "wash hands", rather than "face mask", reducing the speed of COVID-19 outbreak during the following three weeks among 21 countries. Google search for "wash hands" indicated not only the promotion of hand hygiene awareness but might also reflect the extent that people proactively engaged in hand washing. Google searches for "wash hands" provide real-time indicators for transmissionreduction policies and population health literacy in the early stage of the COVID-19 outbreak.3 AbstractThis study hypothesized that national population health literacy might reflect on their keywords searching. We applied Google searches for "wash hands" and "face mask"

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Background and aimsInternet gaming disorder (IGD) is an increasingly important topic and has been included in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) research criteria. This study aims to validate the Chinese version of the Ten-Item Internet Gaming Disorder Test (IGDT-10), a self-reported questionnaire based on DSM-5 IGD criteria, and to estimate the prevalence of IGD in adolescents.MethodsThe IGDT-10 was translated to Chinese as a 10-item questionnaire rated on a 3-point Likert scale to evaluate the symptoms of IGD. Overall, 8,110 students from grade four to senior high who played Internet games were administered the questionnaire. In addition, 76 senior high-school students were interviewed using DSM-5 criteria to determine the optimal cut-off point that ensures adequate sensitivity, specificity, and diagnostic accuracy. The cut-off point was determined using the Youden’s index and optimal diagnostic accuracy.ResultsThe Chinese version of the IGDT-10 showed good internal consistency (Cronbach’s α = .85) and adequate diagnostic efficiency (area under the curve = 0.810). Through interviews, the optimal cut-off point was determined to be five out of the nine criteria (Youden’s index: 42.1%, diagnostic accuracy: 86.8%, sensitivity: 43.8%, and specificity: 98.3%). In this study, the prevalence of IGD among adolescent gamers was 3.1%.ConclusionFindings evidence the validity and diagnostic accuracy of the IGDT-10 in the assessment of IGD.

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PLA2G6-associated neurodegeneration is a major subtype of neurodegeneration with brain iron accumulation. Patients with PLA2G6-associated neurodegeneration usually present degenerative motor symptoms with neuropsychiatric disturbance. This report presents a patient with PLA2G6-related dystonia-parkinsonism, who had neuropsychiatric symptoms preceding movement symptoms. Antipsychotic drug was prescribed, and he developed parkinsonism years later. Differential diagnosis between drug-induced parkinsonism and PLA2G6-related dystonia-parkinsonism could be challenging. PLA2G6 sequencing has to be considered facing a patient with adulthood parkinsonism, especially when it is associated with initial psychiatric symptoms. Our case highlights a common problem treating psychiatric symptoms in neurodegenerative diseases that lead to parkinsonism. The use of antipsychotics requires a special caution in these patients because it may cause extrapyramidal symptoms. Aripiprazole had therapeutic effect on both mood and psychotic symptoms and less impact on motor features, which may be considered an ideal pharmacological approach in treating these patients.

This study investigates the electrical characteristics and physical analysis for an amorphous tungsten-doped indium-zinc oxide thin film transistor with different backchannel passivation layers, which were deposited by an ion bombardment-free process.