Cryptococcus neoformans
assembles two types of
O
-linked glycans on its surface proteins, the more abundant major
O
-glycans that do not contain xylose residues and minor
O
-glycans containing xylose. Here, we demonstrate the role of the Cap6 α1,3-mannosyltransferase in the synthesis of minor
O
-glycans.
Current antifungal drugs have several limitations, such as drug resistance, severe side effects, and a narrow spectrum. Therefore, novel antifungal targets are urgently needed.
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