The uncertainty principle is one of the most remarkable features of quantum mechanics, originally expressed in terms of the standard deviation of two incompatible observables. Alternatively, it can be modified and written in the form of entropy to eliminate the defect in the form of standard deviation, and can also be generalized by including a memory particle that is entangled with the particle to be measured. Herein we consider a realistic scenario where the particle A to be measured is in an open environment and B as quantum memory is under an environment typically characterized by non-Markovian regimes. Specifically, it shows that the quantum memory and the non-Markovian effect can essentially inhibit the increase of uncertainty, however, the quantum memory-assisted uncertainty will finally inflate inevitably, due to that the quantum correlation of the system will be damaged gradually by the noise from the surrounding environments. To be explicit, we study the dynamic evolution of the entropic uncertainty and correlation in open system where both particles experience the noise channels. Meanwhile, we put forward some effective operation strategies to reduce the magnitude of the measurement uncertainty under the open systems. Furthermore, we explore the applications of the uncertainty relation investigated on entanglement witness and quantum channel capacity. Thus, our investigations might offer an insight into quantum measurement estimation in open systems.