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To study the features of cytokines in patients with various forms of neurosyphilis. The complex laboratory examination of patients with neurosyphilis and syphilis without specific lesion of the nervous system was observed in the venereological department of the OSH “Clinical Dermatological and Venereological Dispensary” in Omsk in order to determine the concentration of interleukins - 23, 12p40 in CSF and assess their relationship with the course of syphilitic infection. The presence of regularities and features in the deviation of the immune status in the examined disease was established. Analysis of immunological changes in patients’ cerebrospinal fluid showed that in patients with neurosyphilis, regardless of the presence or absence of clinical symptoms, the levels of IL-23 and IL-12p40 in CSF significantly exceed those in patients without specific lesion of the nervous system.

Objective. To reveal additional laboratory criteria for assessing the affection of the nervous system in case of neurosyphilis. Materials and methods. There was a study of 49 patients with a specific affection of the nervous system. The complex study comprised a clinical examination performed by a dermatovenerologist, a neurologist and an ophthalmologist as well as serologic examination of blood and spinal fluid. The level of IL-6, IL-17 and TNF-α in parallel blood and spinal fluid samples was determined. Results. The authors obtained statistically significant results for the concentration of IL-6 and TNF-α. The increased level of these indices was observed in the spinal fluid of patients with the most severe neurological manifestations of the specific process. Thus, it is evident that changes in this index reflect the severity of affection for all components of the nervous tissue. The described changes demonstrate the autoimmune nature of pathological processes taking place in the nervous system.

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