A review of modern studies on the problem of multimorbidity, its definition, frequency of occurrence, prevalence, medical and social consequences, factors predisposing to its formation, and approaches to diagnosis, therapy, and rehabilitation is presented. According to modern understanding, multimorbidity is the presence of two and / or more chronic diseases that are pathogenetically interconnected and / or coincide in time in one patient.Currently, multimorbidity is becoming an epidemic, affecting people of different ages and gender and with various diseases. The literature describes multiple adverse medical and social consequences of multimorbidity, such as increased rates of hospitalization, disability, and mortality, decreased functional capabilities and quality of life in patients, as well as increased volume, timing, and cost of medical care. Today, issues of the unified terminology, identification of multimorbidity, and the structure and clinical manifestations of associated pathology are being studied. There are single works on the study of possible factors contributing to the formation of multimorbidity. Approaches to management of patients in conditions of multimorbidity are being developed. A more detailed study of the mechanisms of multimorbidity formation and common pathogenetic links of associated diseases will make it possible to develop more effective strategies for the diagnosis, treatment and rehabilitation of multimorbid patients.
Aim of the study was to investigate the role of C-reactive protein as an indicator of multimorbidity in patients with arterial hypertension.Material and methods. A retrospective archival study of the data of 1958 patients with arterial hypertension who were examined and treated at the clinic of the Federal Research Center for Fundamental and Translational Medicine (Novosibirsk) was carried out. 2 groups of patients were allocated depending on the concentration of C-reactive protein in the blood serum: normal and elevated (> 5 mg/l). A comparative analysis of the severity of polymorbidity, as well as clinical, laboratory and biochemical parameters in the selected groups were carried out.Results. It has been established that patients with arterial hypertension with elevated values of C-reactive protein had higher rates of transnosological and transsystemic polymorbidity, accompanied by changes in lipid, carbohydrate and purine metabolism (a decrease in high-density lipoprotein cholesterol, an increase in the concentration of glucose and uric acid in blood serum, an increase in the index atherogenicity), as well as an increase in the content of fibrinogen in the blood serum.Conclusions. The concentration of C-reactive protein in the blood serum can serve as a biochemical marker of polymorbidity in patients with arterial hypertension.
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