Background It remains unclear whether extended lymphadenectomy provides oncological advantages in colorectal cancer. This multicentre RCT aimed to address this issue. Methods Patients with resectable primary colonic cancer were enrolled in four hospitals registered in the COLD trial, and randomized to D2 or D3 dissection in a 1 : 1 ratio. Data were analysed to assess the safety of D3 dissection. Results The study included the first 100 patients randomized in this ongoing trial. Ninety‐nine patients were included in the intention‐to‐treat (ITT) analysis (43 D2, 56 D3). Ninety‐two patients received the allocated treatment and were included in the per‐protocol (PP) analysis: 39 of 43 in the D2 group and 53 of 56 in the D3 group. There were no deaths. The 30‐day postoperative morbidity rate was 47 per cent in the D2 group and 48 per cent in the D3 group, with a risk ratio of 1·04 (95 per cent c.i. 0·68 to 1·58) (P = 0·867). There were two anastomotic leaks (5 per cent) in the D2 group and none in the D3 group. Postoperative recovery, complication and readmission rates did not differ between the groups in ITT and PP analyses. Mean lymph node yield was 26·6 and 27·8 in D2 and D3 procedures respectively. Good quality of complete mesocolic excision was more frequently noted in the D3 group (P = 0·048). Three patients in the D3 group (5 per cent) had metastases in D3 lymph nodes. D3 was never the only affected level of lymph nodes. N‐positive status was more common in the D3 group (46 per cent versus 26 per cent in D2), with a risk ratio of 1·81 (95 per cent c.i. 1·01 to 3·24) (P = 0·044). Conclusion D3 lymph node dissection is feasible and may be associated with better N staging. Registration number: NCT03009227 ( http://www.clinicaltrials.gov).

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AIM to assess results of stapling anastomosis in colorectal surgery. PATIENTS AND METHODS. The results of surgical treatment of 427 patients with rectal cancer and 458 patients with colon cancer (T1-4N0-2M0-1) were analyzed. A circular stapler was used to perform end-to-end (347patients) and side-to-end (80 patients) anastomosis. 164 patients underwent stapling colonic anastomosis. RESULTS. Anastomotic leak rate after stapled colorectal anastomosis was 8,7% (n=37) and was lower after side-to-end anastomosis 3,8% (n=3). Anastomotic leakage developed in only 2 (1,2%) patients after colon anastomosis. CONCLUSION. Proper use of stapling devices and proper surgical technique allow to create reliable anastomosis which safety is comparable the manual one.

Multiple equilibrium solutions of aircraft motion equation are investigated using nongradient based numerical methods and computation of attainable equilibrium sets. The proposed approach may be applied to realistic industrial scale aircraft aerodynamic models based on look-up data tables. Advantages of this method and its joint use with predictorcorrector techniques for continuation and bifurcation analysis of aircraft nonlinear dynamics are discussed. A number of computational examples for aircraft dynamics investigation are presented for a generic airliner aerodynamic model developed within the SUPRA research project -"Simulation of Upset Recovery in Aviation" -funded by the European Union 7 th Framework Program. Nomenclature , , speed, angles of attack and sideslip , linear and angular velocity vectors specified in body-fixed reference frame , pitch and bank Euler angles unit vector of local vertical specified in body-fixed reference frame unit vector along linear velocity identity matrix , aerodynamic force and moment vectors specified in body-fixed reference frame control effectors vector elevator, aileron and rudder deflections projection of angular velocity vector onto speed vector projection of angular velocity vector onto local vertical vector m aircraft mass g gravity acceleration bwing span coefficients characterizing convex hull AES attainable equilibrium set