Background Erosive pustular dermatosis of the scalp (EPDS) is characterized by crusted erosions or superficial ulcerations that lead to scarring alopecia. Objectives and Methods We performed a multicentre retrospective clinical study including 56 patients (29 females and 27 males, mean age 62.7) with a confirmed EPDS in order to describe epidemiology, clinical findings and therapeutic choices of this disease. Results Mechanical/chemical trauma was reported in 28.6%, a previous infection in 10.7%, a previous cryotherapy in 5.4% androgenetic alopecia in 48.2% and severe actinic damage in 25%. Trichoscopy showed absence of follicular ostia, tufted and broken hair, crusts, serous exudate, dilated vessels, pustules and hyperkeratosis. Histopathology revealed three different features, depending on the disease duration. The most prescribed therapy was topical steroids (62.5%), followed by the combination of topical steroids and topical tacrolimus (8.9%), systemic steroids (7.1%) and topical tacrolimus (5.4%). A reduction of inflammatory signs was observed in 28 patients (50%) treated with topical steroids and in all three patients treated with topical tacrolimus. Conclusion The relatively high number of patients collected allowed us to identify a better diagnostic approach, using trichoscopy and a more effective therapeutic strategy, with high-potency steroids or tacrolimus, which should be considered as first-line treatment.

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Abstract:The article presented our reviews on methodological advances in the diagnosis of demodecosis via our own research on demodecosis diagnosis efficiency with the aid of fluorescence lifetime measurement using confocal laser scanning microscopy. Under our supervision, there were 60 patients with acne and rosacea complicated with demodecosis, 60 patients with acne and rosacea without demodecosis, and 30 healthy volunteers. All patients underwent skin scraping and epilation of eyebrows and/or eyelashes, and the examination of skin morphology was conducted using confocal laser scanning microscopy. The research has shown the advantages of in vivo confocal laser scanning microscopy over the conventional microscope.

The article deals with clinical diagnosis and treatment of pityriasis rubra pilaris (PRP). The authors analyze the diagnostic errors, present literature review, and their own observations. The clinical study included 23 patients with pityriasis rubra pilaris: 18 women and 5 men, average age of 54 ± 7.2. The clinical diagnosis of all examined patients was subsequently confirmed by histological analysis of the skin. The primary clinical diagnosis was psoriasis in 15 (65.2%) patients, 6 (26%) patients received treatment for toxic exanthema, and only 2 (8.8%) patients were presumptively diagnosed with pityriasis rubra pilaris. In conclusion, pityriasis rubra pilaris was initially misdiagnosed in 91.2% of patients. Considering the great number of diagnostic errors, we analyzed the main diagnostic and differential diagnostic features of PRP. The most effective of all synthetic retinoids in PRP treatment is acitretin. Although symptomatic improvement in PRP occurs within a month, substantial improvement, even clearing is possible within 4 - 6 months.

The article presents the analysis of the clinical picture of patients with rosacea of different degrees of severity complicated with demodicosis. The dermatovenereology life quality index was evaluated for patients with rosacea in the presence and absence of Demodex mites. Presence of Demodex mites reduces the life quality of patients with rosacea.The duration of pathological processes on the facial skin, as well as the number of relapses were assessed. The course of rosacea was analyzed depending on the species identity of Demodex mites (Demodex folliculorum longus and Demodex folliculorum brevis). In the structure of rosacea diagnoses Demodex folliculorum longus is significantly more prevalent (n = 20; 66.7%) then Demodex folliculorum brevis (n=8; 26.7).

Provided data on the effectiveness of a new peptide complex in the treatment of female-type hair loss in postmenopausal patients. Thus, the use of the complex contributed to the transition of follicles from the resting stage to the growth stage. As a result, the hair density increased