Background: Bone metastatic disease affect a patient’s quality of life. Aim: Evaluating possible stratification factors affecting the efficacy of different schedules of zoledronic acid on SREs. Patients and Methods: A randomized, clinical trial at Zagazig university hospitals. 108 Patients were enrolled to receive zoledronic acid 4 mg (A and B groups=12 and 4 weeks, respectively) for 2 years. Results: Regarding age, tumour type, types of bone metastasis and number of bone metastasis, there was an insignificant difference between both groups. However, 3 monthly regimen of zoledronic acid gave better results in solitary than multiple bone metastases. Regarding pretreatment ECOG, there was an insignificant difference between between both groups. However, 3 monthly regimen of zoledronic acid gave better results in pre-treatment ECOG 1and ECOG 2 than ECOG 3. Conclusion: A 3-monthly regimen of zoledronic acid is more effective in management of solitary or few sites of bone metastasis, osteoblastic bony lesions and patients with good performance status. Recommendations: We recommend a larger sample size and the study should include a homogenous groups of patients so we can judge well on different stratifications factors that can affect efficacy of 3- monthly regimen of zoledronic acid.
Background: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in the world and it`s prevalence in Egypt has been rising in the last few years. The aim was to study determinants of HCC in Clinical Oncology and Nuclear Medicine Department in Zagazig University Hospitals. Methods: This is a retrospective chart review of 538 patients with HCC conducted from 2012 to 2017. Analysis of data in files was done to study the determinants of HCC. Results: The majority of cases (77%) were male, about 71.7% of patients were from urban areas. Age of majority of cases was in 50s (40%). (99.71%) of patients were of cirrhotic liver. HCV antibody was detected in serum of (89.92%) of studied cases while hepatitis B virus infection was detected in only (3.10%) of cases. Conclusion: HCC is a major health problem in Zagazig and its incidence is increasing. The high prevalence of HCV infection makes screening programs and following up of HCV patients is a very important tool for early detection of mild HCCs cases.
Background: Bladder cancer is the ninth most common cancer worldwide, with an estimated 430 000 new cases in 2012. Transitional Cell Carcinoma (TCC) represents 90% to 95% of malignant bladder tumors. Objective: This retrospective observational study was done to analyze age, gender, histological characteristics in patients with bladder cancer. Patients and Methods: The whole number of UBC cases diagnosed, treated at the
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