Cucurbituril-based nanoparticles (CB[6]NPs) serve as new efficient vehicles for delivery of hydrophobic drugs, which have unique features including (1) a high drug loading capacity and efficiency, (2) noncovalently tunable surfaces, (3) efficient delivery of hydrophobic drugs into a cancer cell by receptor-mediated endocytosis, and (4) facile release of drugs into cytoplasm, which enhances the pharmaceutical effects of the drugs.
The work demonstrates a judicious approach to achieve hepatocyte cell-targeted highly efficient gene delivery by utilizing a supramolecular complex of galactosylated cucurbituril and dextran-spermine conjugates.
Ein supramolekularer Klettverschluss mit bemerkenswerter mechanischer und chemischer Reversibilität und hervorragender Adhäsion wurde auf der Basis von multivalenten Wirt‐Gast‐Anordnungen erhalten (siehe Schema). Mit Cucurbit[7]uril (CB[7]) als Wirtspezies und Aminomethylferrocenyl (Fc) als Gastspezies funktionalisierte Siliciumoberflächen (blau) halten wegen der außerordentlichen Affinität dieser Komponenten unter Wasser zusammen.
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