Screening a genomic library oT Drosophih rwhmgosrer DNA with a human_firrcDNA probe resulted in the isolation of DNA clones thaw apparently belonged to two different DNA regions of the Drosophikr genome. Subsequently. corresponding Drosophih cDNA ciones were isolated. Nucleotide sequence analysis indicated that these cDNA clones originated from two different genes. which were called Djitrl and Djirr2. From overlappihig Dfirl cDNA clones, a composite cDNA could be constructed and analysis of its nucleotide sequence revealed the coding sequence for a protein of 899 amino acid residues. This protein. designated Dfurinl. exhibited striking sequence homology to human furin and contained the same protein domains except for the cysteine-rich region. Furthermore. unlike human furin. Dfurinl possessed an extended amino-terminal region in which a potential transmembranc anchor was present.Subtilisin-like proprotein processing enzyme: Furin; DTurin I: Drosupllilcl rr~c/trr~ogcrs~er
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