Highly enantioselective cascade reactions for the synthesis of fluoroindanes and chromanols derivatives are described. The cascade reactions consisted of either a double Michael reaction or Michael-hemiacetal formation via the addition of fluorobis(phenylsulfonyl)methane (FBSM) to enals. The final products were obtained in good yields with excellent stereoselectivities.
A facile method for the intermolecular Stetter reaction of various Michael acceptors with acetaldehyde as a biomimetic acylanion source was realized using N-heterocyclic carbene catalysis. This catalytic system has also been applied to the enantioselective Stetter reaction and resulted in moderate to good enantioselectivities for the corresponding Stetter products.
This feature focuses on a reagent chosen by a postgraduate, highlighting the uses and preparation of the reagent in current research 2816 spotlight Fluorobis(phenylsulfonyl)methane (FBSM)
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