Background-Antiplatelet drugs are effective in preventing recurrence of atherosclerosis in type 2 diabetic patients.However, the efficacy and usefulness of 2 different antiplatelet drugs, aspirin and cilostazol, in the progression of carotid intima-media thickening are unknown. 001).In a regression analysis adjusted for possible confounding factors such as lipid levels and hemoglobin A 1c , the improvements in common carotid artery intima-media thickness with cilostazol treatment over aspirin treatment remained significant. Conclusions-Compared with aspirin, cilostazol potently inhibited progression of carotid intima-media thickness, an established surrogate marker of cardiovascular events, in patients with type 2 diabetes mellitus. Clinical Trial Registration-URL: http://www.clinicaltrials.gov. Unique identifier: C000000215.

AMP-activated protein kinase (AMPK) is tightly regu-Mammalian AMP-activated protein kinase (AMPK) 1 plays a key role in the regulation of energy homeostasis and is highly conserved among animals, plants, and fungi (reviewed in Refs.

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