Background and aims To observe the effects of long term hydroxychloroquine treatment on blood lipid and left ventri-clar function of systemic lupus erythematosus(SLE) patients. Methods 72 patients with SLE were randomly divided into two groups: Hydroxychloroquine treatment group(n=36)and non-hydroxychloroquine group(n=36). The level of blood lipid, left ventricular end-diastolic diameter (LVEDD), left ven-tricular end-systolic diametef (LVESD), interventricular septum thickness(IVST), left ventricular posterior wall thickness (LVPWT), fractional shortening rate(FS), left ventricular ejection fraction(LVEF), E/A were mearsured before, 6 month, 12 month and 2 years after the treatment. Results The long term applies of hydroxychloroquine can bring statistically different of TC, TG, LDL and HDL to SLE patients. LVEDD, LVWPT and E/A were statistically different (p<0.05) before and after hydroxychloroquine were used. Conclusions The long term applies of hydroxychloroquine can improve the lipidic metabolism and left ventricular function in SLE patients.
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