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Background: To evaluate the short-term outcomes of switching to ranibizumab in aflibercept-resistant polypoidal choroidal vasculopathy (PCV). Methods: This retrospective study included 18 eyes diagnosed with aflibercept-resistant PCV. All patients were treated with two to four consecutive ranibizumab injections at 4–5-week intervals. The best-corrected visual acuity (BCVA), and central retinal thickness (CRT) values before and after switching to ranibizumab were compared. The proportion of eyes showing ≥100 µm decrease in retinal thickness and/or complete resolution of fluid after switching was identified. Results: The mean number of aflibercept injections before switching was 5.7 ± 3.3. After switching, a mean of 2.8 ± 0.6 consecutive ranibizumab injections was performed. The mean logarithm of minimal angle of resolution (logMAR) BCVA was 0.41 ± 0.26 (Snellen equivalents = 20/51) before switching, and 0.40 ± 0.30 (20/50) after switching (p = 0.574). The mean CRT was 422.2 ± 152.4 µm before switching, and 400.7 ± 182.0 µm after switching (p = 0.236). A decrease in CRT of ≥100 µm, and/or complete resolution of fluid was noted in three eyes (16.7%). Conclusions: Switching to ranibizumab in aflibercept-resistant polypoidal choroidal vasculopathy was not effective in most patients, suggesting the need for further investigation to seek more effective treatment options for this condition.

Most commercially available herbicides contain surfactants as co-formulants to increase adhesion and absorption by plant leaves. Ethoxylated amines, one of the most used surfactants, are non-ionic and derived from animal fats. They represent a class of surfactants with similar structural features, including polyethoxylated tallow amine (POEA). POEA is widely used in glyphosate, glufosinate-containing herbicides. In 2015, the European Food Safety Society (EFSA) concluded that POEA was more toxic than glyphosate when tested in glyphosate-based formulations. [1] They also attributed the poisoning following ingestion by humans to the presence of POEA.However, there are few in vivo metabolic studies on post-acute herbicide poisoning in humans. Therefore, we investigated the change in the blood concentration of POEA over time and the clinical presentations in patients with acute herbicide poisoning.

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Recently, the diverse needs of the drivers for in-vehicle infotainment systems are increasing rapidly. As a result, the infotainment systems are equipped with more convenient and human-friendly high-tech features. In this paper, we designed and implemented in-vehicle multimedia infotainment system based on embedded system that was applied various multimedia to in-vehicles. The proposed system can support independent display on each screen for the multi-channel multimedia source based on one processor(1 CPU). Therefore, our system can be reduced costs compared to other systems. This system not only displays the video and audio data in storage devices but also displays CAM, T-DMB, and DVB-T multimedia contents which are supplied in real-time services. Also, our system could multi-screen displays multimedia data in smart phone using Wi-Fi. We expect that in-vehicle infotainment systems like AVN(Audio video navigation) and RSE(Rear Seat Entertainment) could be used in various applications and reduced costs.

MOST(Media Oriented Systems Transport) is a network protocol for vehicle multimedia, where it guarantees large bandwidth and reliability. However, previous MOST device utilized I2C or I2S communication method to data manage or transfer, Bandwidth of MOST have increased and additional equipments are added to one device, requiring a larger form of bandwidth communication method. Therefore, this research suggests of the methods in improving the efficiency of asynchronous data transfer, and suggest an algorithm, which will improve the reliability.