Background It is assumed that moderate exercise may improve resistance to infection and reduce inflammation, but there are limited data to support this assumption in an infection model. Methods BALB/cJ mice were assigned to the following groups: no exercise (NON-EX), 1 session of acute exercise (A-EX), or chronic exercise for ~3.5 months (C-EX). Mice were infected with influenza (C-EX mice infected at rest; A-EX mice infected 15 min after exercise). Results C-EX mice demonstrated the lowest severity of infection, assessed by body weight loss and food intake. There was less virus in the lungs at day 5 after infection in C-EX and A-EX mice compared with NON-EX mice (P = .02) and less virus at day 2 after infection only in C-EX mice (P = .07). Soon after infection (day 2), interleukin 6 (IL-6), monocyte chemoattractant protein 1 (MCP-1), macrophage inflammatory protein 1β, and tumor necrosis factor α in the bronchoalveolar lavage (BAL) fluid were lower in C-EX and A-EX than in NON-EX mice. At day 5 after infection, the BAL fluid from C-EX (but not A-EX) mice had less IL-6, interleukin 12p40, granulocyte colony-stimulating factor, keratinococyte-derived chemokine, and MCP-1 than that from NON-EX mice. A trend toward reduced immunopathologic response was found in C-EX mice. Conclusions Chronic exercise resulted in reduced symptoms, virus load, and levels of inflammatory cytokine and chemokines. Acute exercise also showed some benefit, which was limited to the early phase of infection.

The purpose of this study was to examine the effect of 8 weeks suspension-rail giat traing on ankle ROM, static blance, dynamic balance and gait speed. METHODS: The participants were composed of thirty-six stroke patients who were diagnosed hemiplegia in our study. As for group classification, subjects were divided into two group: 8 weeks suspension-rail giat traing group and control group. Storke patients participated in suspension-rail gait training program and traditional physical therapy for 8 weeks. We measured their ankle ROM (goniometer), static balance (Berg Balance Scale, BBS), dynamic balance (Timed Up & Go, TUG) and gait speed (10 m walking test, 10MWT), when before begun the program, after 8 weeks. RESULTS: After 8 weeks, suspension-rail giat traing group showed significant improvement on ankle ROM (p<.001), static balance (p<.001), gait speed (p<.05) than control group. But dynamic balance were not founded significant difference. CONCLUSIONS: The result indicated that suspension-rail gait training would be effective exercise to gait speed and static balance for patients with hemiplegia stroke.

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