The current classification system of hereditary dentin defects was proposed in 1973 (Shields, Bixler, & el-Kafrawy AM, 1973) based on clinical and radiographic information without knowledge of the underlying molecular pathophysiology: three types of dentinogenesis imperfecta (DGI-I, DGI-II, and DGI-III) and 2 types of dentin dysplasia (DD-I and DD-II).Dentin sialophosphoprotein (DSPP) is the most abundant non-collagenous component in dentin and a member of the acidic secretory calcium-binding phosphoprotein (SCPP) gene family (Kawasaki & Weiss, 2006). After DSPP is synthesized, it undergoes extensive post-
Objective. To explore how diabetes mellitus impacts chronic rhinosinusitis clinically and on structured histopathology to provide insights on new potential chronic rhinosinusitis endotypes.Study Design. Retrospective cohort study. Setting. Tertiary academic center.Methods. A retrospective study of chronic rhinosinusitis patients who underwent functional endoscopic sinus surgery from 2015 to 2020 was performed. Structured 13-variable histopathology reports were generated from intraoperative sinonasal specimens. These variables were compared against demographic factors, comorbidities, culture data, and preoperative Lund-Mackay and SNOT-22 scores using logistic regression.Results. There were 411 patients, including 52 diabetics. Diabetes was associated with higher mean body mass index (34.9 vs 29.2; p < .001), age (57.8 vs 48.0; p < .001), and Gram-negative (40.2% vs 22.7%; p < .030) and coagulasenegative Staphylococcus (49.0% vs 28.5%; p = .008) culture rates. Black (23.1% vs 18.7%) and Hispanic (23.1% vs 8.6%) races were more common with diabetes (p = .026). Gender, smoking, polyp status, and Lund-Mackay and SNOT-22 scores did not differ between groups. Diabetics had more fungal elements (13.5% vs 3.3%, p = .018); no other histopathological differences were seen. When controlling for demographic variables and comorbidities, diabetes independently predicted the presence of fungal elements (HR 4.38, p = .018). Conclusion.Diabetic chronic rhinosinusitis patients demonstrated increased fungal elements on structured histopathology. Other histopathological features were unaffected by diabetes. These findings may have important implications on the medical and surgical management of diabetic chronic rhinosinusitis patients in which early fungal disease assessment is paramount.
Pucciniastraceae, Rosaceae, urediniospore Rubus pungens ('Korean creeping raspberry'; Rosaceae) is a deciduous, broad-leaved tree native to East Asia. Its edible fruit is consumed fresh or used as a medicinal ingredient for diabetes and asthma (Moon, 1991). In May 2021, symptoms of a rust disease were observed on Rubus pungens in the Korea National Arboretum, Pocheon, Korea, with a disease incidence of 50% amongst the 30 plants surveyed. Bright yellow-orange rust pustules of the uredinial stages were found on both sides of the infected leaves. The pustules were often erumpent and 1 to 3 mm in diameter (Figure 1).
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