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To develop a novel tacrolimus-loaded solid dispersion with improved solubility, various solid dispersions were prepared with various ratios of water, sodium lauryl sulfate, citric acid and carboxylmethylcellulose-Na using spray drying technique. The physicochemical properties of solid dispersions were investigated using scanning electron microscopy, differential scanning calorimetery and powder X-ray diffraction. Furthermore, their solubility and dissolution were evaluated compared to drug powder. The solid dispersion at the tacrolimus/CMC-Na/sodium lauryl sulfate/citric acid ratio of 3/24/3/0.2 significantly improved the drug solubility and dissolution compared to powder. The scanning electron microscopy result suggested that carriers might be attached to the surface of drug in this solid dispersion. Unlike traditional solid dispersion systems, the crystal form of drug in this solid dispersion could not be converted to amorphous form, which was confirmed by the analysis of DSC and powder X-ray diffraction. Thus, the solid dispersion system with water, sodium lauryl sulfate, citric acid and CMC-Na should be a potential candidate for delivering a poorly water-soluble tacrolimus with enhanced solubility and no convertible crystalline.

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This article explores the first female president of South Korea, Park Geun-Hye, and her substantive representation of women. Though Park is one of many women executives from Asia taking the family route to power, her presidency still may lead to the implementation of women-friendly policies once elected. Park's government has expanded women-related policy areas first developed by previous progressive governments, but not consistently. Though mixed, her performance shows improvement over the previous conservative president, who shares Park's party affiliation. Since we can control for partisanship, Park administration's efforts on behalf of women prove particularly compelling. While advantaged by her political lineage, her government offers important policy benefits to women.

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Tsai Ing-wen was elected as the first woman president of Taiwan in 2016 and re-elected in 2020. Did the prospect of “the first woman president” shape the expectations of the changes she may bring about regarding women and lesbian, gay, bisexual, trans, and queer (LGBTQ) rights? Analyzing 35 in-depth elite interviews, this paper demonstrates Tsai’s campaign did not benefit much from “the first woman” slogan, her cabinet included fewer women than her predecessors’, and she could not proactively push for marriage equality after the elections. Tsai’s case illuminates the constraints women leaders face in promoting representation for marginalized groups.