In this study, mung bean-based nanoporous activated carbons with different pore properties were prepared by varying the mass ratio of activating agent (KOH) and activation temperature. The low-temperature nitrogen adsorption...
Upload this completed form to website with submission ARTICLE INFORMATION Fill in information in each box below Article Type Research article Article Title Inhibitory effect of genomic DNA extracted from Pediococcus acidilactici on Porphyromonas gingivalis lipopolysaccharide-induced inflammatory responses Running Title (within 10 words) P. acidilactici gDNA inhibits P. gingivalis LPS-induced inflammatory responses
A new cold neutron triple-axis spectrometer (Cold-TAS) was recently constructed at the 30 MW th research reactor, HANARO. The spectrometer, which is composed of neutron optical components and radiation shield, required a redesign of the segmented monochromator shield due to the lack of adequate support of its weight. To shed some weight, lowering the height of the segmented shield was suggested while adding more radiation shield to the top cover of the monochromator chamber. To investigate the radiological effect of such change, we performed MCNPX simulations of a few different configurations of the Cold-TAS monochromator shield and obtained neutron and photon intensities at 5 reference points just outside the shield. Reducing the 35% of the height of the segmented shield and locating lead 10 cm from the bottom of the top cover made of polyethylene was shown to perform just as well as the original configuration as radiation shield excepting gamma flux at two points. Using gamma map by MCNPX, it was checked that is distribution of gamma. Increased flux had direction to the top and it had longer distance from top of segmented shield. However, because of reducing the 35% of the height, height of dissipated gamma was lower than original geometry. Reducing the 35% of the height of the segmented shield and locating lead 10cm from the bottom of the top cover was selected. After changing geometry, radiation dose was measured by TLD for confirming tester's safety at any condition. Neutron(0.21 μSvhr -1 ) and gamma(3.69 μSvhr -1 ) radiation dose were satisfied standard(6.25 μSvhr -1 ).
In the present study, we aimed to examine the inhibition of genomic DNA from
Lactiplantibacillus plantarum
(LpDNA) on
Porphyromonas gingivalis
lipopolysaccharide (PgLPS)-induced
inflammatory responses in RAW264.7 cells. Pretreatment with LpDNA for 15 h
significantly inhibited PgLPS-induced mRNA expression and protein secretion of
interleukin (IL)-1β, IL-6, and monocyte chemoattractant protein-1. LpDNA
pretreatment also reduced the mRNA expression of Toll-like receptor (TLR)2 and
TLR4. Furthermore, LpDNA inhibited the phosphorylation of mitogen-activated
protein kinases (MAPKs) and the activation of nuclear factor-κB
(NF-κB) induced by PgLPS. Taken together, these findings demonstrate that
LpDNA attenuates PgLPS-induced inflammatory responses by regulating MAPKs and
NF-κB signaling pathways through the suppression of TLR2 and TLR4
expression.
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