Summary
TGF-β is well known to play a critical role in diabetic kidney disease, and ongoing clinical studies are testing the potential therapeutic promise of inhibiting TGF-β production and action. An aspect of TGF-β action that has not received much attention is its potential role in explaining sex-related proclivity for kidney disease. In this review, we discuss recent studies linking TGF-β signaling to sex-related effects in diabetic kidney disease and suggest targets for future studies.
In this study, the structural properties of Second Higher-Harmonic Aeroacoustic Rotor Test blades are determined using state-of-the-art test techniques. The measurement includes bending and torsion stiffnesses, section geometric offsets, and mass and inertia properties. Several Second Higher-Harmonic Aeroacoustic Rotor Test blades, including the original instrumented blade used for the wind-tunnel test campaign in 2001, as stated by Yu et al. ) are used for the activity. A finite element-based cross-section analysis combined with an x-ray computer tomography technique is employed for the cases where no mechanical measurement is available or attempted. The resulting structural properties are correlated against the earlier estimated values, which have extensively been used in the literature for the validation of the Second Higher-Harmonic Aeroacoustic Rotor Test rotor. A substantial deviation is observed between the present measurement and the earlier property result. The comprehensive rotor dynamics analysis is performed to quantify the impact of the measured blade properties on the aeromechanics behavior of the rotor. The location of the center of gravity is demonstrated to be the most influential factor affecting the deviation and the sensitivity of the aeroelastic response of the rotor. Nomenclature C T = thrust coefficient; T∕ρRΩ 2 πR 2 c = chord, m EA = axial stiffness, N EI β = flap-bending stiffness, N · m 2 EI ζ = chord-bending stiffness, N · m 2 GJ = torsion stiffness, N · m 2 I θ = polar mass moment of inertia per length, kg · m M = hover tip Mach number R = rotor radius, m T = applied torque, N · m α s = shaft tilt angle, deg μ = advance ratio ρ = air density, kg∕m 3 Ω = rotor nominal speed, rad∕s
For a CFD (computation fluid dynamics)/CSD (computational structural dynamics) coupling, appropriate data exchange strategy is required for the successful operation of the coupling computation, due to fundamental differences between CFD and CSD analyses. This study aims at evaluating various data transfer schemes of a loose CFD/CSD coupling algorithm to validate the higher harmonic control aeroacoustic rotor test (HART) data in descending flight. Three different data transfer methods in relation to the time domain airloads are considered. The first (method 1) uses random data selection matched with the timewise resolution of the CSD analysis whereas the last (method 2) adopts a harmonic filter to the original signals in CFD and CSD analyses. The second (method 3) is a mixture of the two methods. All methods lead to convergent solutions after a few cycles of coupling iterations are marched. The final converged solutions for each of the data transfer methods are correlated with the measured HART data. It is found that both method 1 and method 2 exhibit nearly identical results on airloads and blade motions leading to excellent correlations with the measured data while the agreement is less satisfactory with method 3. The reason of the discrepancy is identified and discussed illustrating CFD-/CSD-coupled aeromechanics predictions.
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