Introduction: Lactose intolerance affects 70% of the world's population. Lactose promotes calcium absorption and can act as a prebiotic. Objective: To determine whether there are differences in the symptoms and signs characteristic of lactose intolerance in patients aged 16 to 30 years of the groups to which removal of lactose milk was administered compared with lactose-free milk. Method:Randomized doubleblind controlled clinical trial of equivalence, parallel design with two groups, each group was randomly allocated to 25 patients of either sex, the intervention group was administered removal of lactose milk containing 15% of lactose and the group of Control lactose-free milk, the effect was assessed by a questionnaire of symptoms and signs of lactose intolerance validated by experts. The magnitude of the differences in both groups was estimated by the T Student test. Results: 76% of the participants were of the fem sex, the average age of the participants was 26 years ± 3.97, in the experimental group 100% of the participants did not consume milk. In the comparison test of groups is rejected the null hypothesis that the differences were greater than 10%, the difference being obtained from 9 percent that was within the margin of equivalence of a 10% maximum for both treatments that are considered clinically acceptable, being p < 0.05 for each of the symptoms and signs of lactose intolerance. Conclusions: It has been shown that the intervention with removal of lactose milk containing 15% of lactose is sufficiently similar to the control group; we can consider it as equivalent from the clinical and statistical point of view.
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