Background : Head and neck squamous cell carcinoma (HNSCC) are head and neck cancers. On the other hand, ferroptosis is a novel iron-dependent and ROS reliant type of cell death observed various disease conditions. Method : We constructed a prognostic multilncRNA signature based on ferroptosis-related differentially expressed lncRNAs in HNSCC. Results : We identified 25 differently expressed lncRNAs associated with prognosis of HNSCC. Kaplan-Meier analyses revealed the high-risk lncRNAs signature associated with poor prognosis of HNSCC. Moreover, the AUC of the lncRNAs signature was 0.782, underscoring their utility in prediction HNSCC prognosis. Indeed, our risk assessment model was superior to traditional clinicopathological features in predicting HNSCC prognosis. GSEA revealed the immune and tumor-related pathways in the low risk group individuals. Moreover, TCGA revealed T cell functions including cytolytic activity, HLA, regulation of inflammationp, co-stimulation, co-inhibition and coordination of type II INF response were significantly different between the low-risk and high-risk groups. Immune checkpoints such as PDCD-1 (PD-1), CTLA4 and LAG3, were also expressed differently between the two risk groups. Conclusion: A novel ferroptosis-related lncRNAs signature impacts on the prognosis of HNSCC.

Abstract:The use of spectral features to estimate leaf area index (LAI) is generally considered a challenging task for hyperspectral data. In this study, the hyperspectral reflectance of winter wheat was selected to optimize the selection of spectral features and to evaluate their performance in modeling LAI at various growth stages during 2008 and 2009. We extracted hyperspectral features using different techniques, including reflectance spectra and first derivative spectra, absorption and reflectance position and vegetation indices. In order to find the best subset of features with the best predictive accuracy, partial least squares regression (PLSR) and variable importance in projection (VIP) were applied to estimated LAI values. The results indicated that the red edge-NIR spectral region (680 nm-1300 nm) was the most sensitive to LAI. Most features in this region exhibited a high correlation with LAI and had higher VIP values, especially the first derivative waveband at 750 nm (r = 0.900, VIP = 1.144). Adding a large number of features would not

BackgroundNonalcoholic fatty liver disease (NAFLD) is the most common liver disease in the world. Hydrogen sulfide (H2S) plays an important role in physiology and pathophysiology of liver. However, whether exogenous H2S could mitigate the hepatic steatosis in mice remains unclear. The aim of this study is to evaluate the effects of H2S on fatty liver.MethodsC57BL/6 mice were fed with either a high-fat diet (HFD) or a normal fat diet (NFD) for 16 weeks. After 12 weeks of feeding, the HFD-fed mice were injected one time per day with NaHS or saline for the followed 4 weeks.ResultsCompared to NFD, HFD could induce an accumulation of lipids in liver and a damage of hepatic structure. Compared to saline treatment, in the liver of HFD fed mice H2S treatment could significantly (1) recover the structure; (2) decrease the accumulation of lipids including triglyceride (TG) and total cholesterol (TC); (3) decrease the expression of fatty acid synthase (FAS) and increase the expression of carnitine palmitoyltransferase-1 (CPT-1); (4) reduce malondialdehyde (MDA) levels; (5) increase the activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx).ConclusionH2S could mitigate the fatty liver by improving lipid metabolism and antioxidant potential in HFD-induced obese mice.

BackgroundMyopic foveoschisis (MF) is among the leading causes of visual loss in high myopia. However, it remains controversial whether internal limiting membrane (ILM) peeling or gas tamponade is necessary treatment option for MF.MethodsPubMed, EMBASE, CBM, CNKI, WANFANG DATA and VIP databases were systematically reviewed. Outcome indicators were myopic foveoschisis resolution rate, visual acuity improvement and postoperative complications.ResultsNine studies that included 239 eyes were selected. The proportion of resolution of foveoschisis was higher in ILM peeling group than non-ILM peeling group (OR = 2.15, 95% CI: 1.06–4.35; P = 0.03). The proportion of postoperative complications was higher in Tamponade group than non-Tamponade group (OR = 10.81, 95% CI: 1.26–93.02; P = 0.03). However, the proportion of visual acuity improvement (OR = 1.63, 95% CI: 0.56–4.80; P = 0.37) between ILM peeling group and non-ILM peeling group and the proportion of resolution of foveoschisis (OR = 1.80, 95% CI: 0.76–4.28; P = 0.18) between Tamponade group and non-Tamponade group were similar.ConclusionsVitrectomy with internal limiting membrane peeling could contribute to better resolution of myopic foveoschisis than non-peeling, however it does not significantly influence the proportion of visual acuity improvement and postoperative complications. Vitrectomy with gas tamponade is associated with more complications than non-tamponade and does not significantly influence the proportion of visual acuity improvement and resolution of myopic foveoschisis.Electronic supplementary materialThe online version of this article (10.1186/s12886-017-0562-8) contains supplementary material, which is available to authorized users.

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The effects of MNS on atrial electrical remodelling and AF inducibility might be associated with the cholinergic anti-inflammatory pathway.

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The topographie wetness index (TWl), frequently used in approximately eharaeterizing the spatial distribution of soil moisture and surfaee saturation within a watershed, has been widely applied in topography-related geographical proeesses and hydrologieal models. However, it is still questionable whether the current algorithms of TWl can adequately model the spatial distribution of topographic characteristics. Based upon the widely-used multiple flow direction approach (MFD), a novel MFD algorithm (NMFD) is proposed for improving the TWl derivation using a Digital Elevation Model (DEM) in this study. Compared with MFD, NMFD improves the mathematical equations of the contributing area and more precisely calculates the effective contour length. Additionally, a varying exponent strategy is adopted to dynamieally determine the downslope flow-partition exponent. Finally, a flowdirection tracking method is employed to address grid cells in flat terrain. The NMFD algorithm is first applied to a catchment located upstream of the Hanjiang River in China to demonstrate its accuracy and improvements. Then NMFD is quantitatively evaluated by using four types of artificial mathematical surfaces. The results indieate that the error generated by NMFD Is generally lower than that computed by MFD, and NMFD is able to more accurately represent the hydrological similarity of watersheds.