We developed a rhodium-catalysed decarbonylative C(sp2)–H alkylation method for indolines. This reaction facilitates the use of alkyl carboxylic acids and their anhydrides as a cheap, abundant, and non-toxic alkyl source...
We developed a novel access to indoloindolone by a rhodium-catalyzed intramolecular acylation of 2-(indol-1-yl)benzoic acids. This reaction proceeds via the in situ formation of a mixed anhydride under redox-neutral reaction conditions. Preliminary mechanistic investigations revealed that the in situ-formed mixed anhydride participates in the C–H activation step, which is facilitated by a RhI catalyst. The utility of this reaction was demonstrated by a large-scale reaction.
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