This novel device was safe and effective for its intended use of separating tissues for a desired duration. A clinical study will commence to evaluate the safety and efficacy of this device during irradiation in patients with prostate cancer.
In domestic roosters, which were originally seasonal breeders and that are now kept under unnatural and unchanging conditions throughout the year, fertility peaks at 32 weeks of age (96%) but it subsequently declines rapidly to only 5% at 110 weeks despite the fact that roosters can live for about 10 years. Roosters exhibiting this low-fertility syndrome have reduced levels of spermatozoa in the ejaculate. Concomitantly, however, superabundant but apparently normal spermatozoa are found attached to Sertoli cells and, in addition, the seminiferous epithelium fails to show evidence of the regression of atrophy that characterizes both aging non-seasonal breeders and true seasonal breeders during non-reproductive periods. This syndrome of premature low fertility appears to stem from impaired spermiation with resultant retention of spermatozoa by Sertoli cells. To examine this problem, we compared intratesticular incorporation of 3H-thymidine between high-fertility (32-week-old) and low-fertility (82-week-old) roosters. Radioactivity associated with spermatozoa, 33 days post-injection, was almost 50% higher in the low-fertility roosters than in the high-fertility ones. By contrast, both groups showed similar characteristics with respect to a) intratesticular incorporation of 3H-thymidine, b) dynamics of spermatogenesis, c) intratesticular level of radioactivity just before the initiation of spermiation, and d) the duration of both spermatogenesis and the time required for sperm to pass through the genital tract. Our results confirm that intratesticular retention of sperm occurs in roosters with premature low-fertility syndrome and suggest new possibilities for the study of the complex relationship between Sertoli cells and spermatozoa and the effects of this relationship on fertility.
The current laser atherectomy technologies to treat patients with challenging (to‐cross) total chronic occlusions with a step‐by‐step (SBS) approach (without leading guide wire), are lacking real‐time signal monitoring of the ablated tissues, and carry the risk for vessel perforation. We present first time post‐classification of ablated tissues using acoustic signals recorded by a microphone placed nearby during five atherectomy procedures using 355 nm solid‐state Auryon laser device performed with an SBS approach, some with highly severe calcification. Using our machine‐learning algorithm, the classification results of these ablation signals recordings from five patients showed 93.7% classification accuracy with arterial vs nonarterial wall material. While still very preliminary and requiring a larger study and thereafter as commercial device, the results of these first acoustic post‐classification in SBS cases are very promising. This study implies, as a general statement, that online recording of the acoustic signals using a noncontact microphone, may potentially serve for an online classification of the ablated tissue in SBS cases. This technology could be used to confirm correct positioning in the vasculature, and by this, to potentially further reduce the risk of perforation using 355 nm laser atherectomy in such procedures.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.