The evaluation of the maximum and cumulative response is an important issue for the seismic design of new base-isolated buildings. This study predicts the maximum and cumulative response of a 14-story reinforced concrete base-isolated building using a set of pushover analyses. In the proposed pushover analysis method, the maximum and cumulative responses of the first and higher modes are evaluated from the nonlinear analysis of equivalent single-degree-of-freedom (SDOF) models. Then, the maximum local responses are predicted by enveloping the two pushover analysis results by referring to the contribution of the first and higher modal responses, while the cumulative strain energies of the lead-rubber bearings and steel dampers are predicted from the cumulative response of the first mode. The results reveal that the responses predicted by the proposed set of pushover analyses have satisfactory accuracy.
The human Sept4/Bradeion GTPase (56Kda) is specifically expressed in colorectal cancer, malignant melanoma, prostate cancer and other urologic cancers such as renal cell carcinoma and bladder cancer. Significance of Bradeion is that, 1) 'all or none' expression, 2) no genetic alterations among patients, and 3) strong tissue-and cell typespecificity. This character satisfies the desired criteria as a target to monitor and control cancer. With the advent of current technology development in nano-scale, we have succeeded to develop the effective serum test for early diagnosis of cancer. Fluorescence correlation spectroscopy (FCS) can directly and quickly analyse protein-protein binding in a sample solution by reflecting the molecular weight of the labeled molecules. We present a novel and successful diagnostic methods by the quantitative detection of Sept4/Bradeion in the patients' serum using monoclonal antibodies. The resulting diagnostic efficacy was as follows; 100% (colorectal cancer), 89.0 % (prostate cancer), 92.3 % (renal cell carcinoma), and 89.0 % (bladder cancer). More importantly, the increased Bradeion titers decreased to the normal level after one week (polypectomy with colonoscope) to 3 weeks after surgical detection of the cancer.
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