ABSTRACT-Various proinflammatory mediators are believed to be involved in the processes and symptoms of ulcerative colitis (UC). To determine whether endogenous kinin enhances the severity of UC, we induced experimental colitis (EC) in kininogen-deficient mutant rats and tested the effect of a nonpeptide B2 receptor antagonist. EC was induced in male kininogen-deficient Brown Norway-Katholiek rats (BN-Ka) and normal Brown Norway-Kitasato rats (BN-Ki) with 5% dextran sulfate sodium (DSS). SpragueDawley rats (SD) were also used. Colon length, body weight and hematocrit were determined for 7 days. Effects of FR173657, an orally active B2 antagonist, were tested. The colon length was shortened in BN-Ki with DSS treatment, but not in BN-Ka, and the difference between their lengths was significant. The hematocrit value was also reduced in BN-Ki, and the difference in hematocrit between BN-Ki and BN-Ka was significant. In SD, shortening of the colon and reduction in hematocrit were also observable, and both were blunted by FR173657. The survival rate in SD given DSS for 7 days was 68%, but FR173657 treatment restored it significantly to 100%. These results suggest that the endogenous kinins generated from the kallikrein-kinin system have a significant role in the development of EC.

São feitas algumas considerações sobre metabolismo de resistência de insetos à inseticidas e papel dos sistemas de enzimas nesse processo. Os autores analisaram através da técnica de eletroforese, o "pool esterasico" de uma amostra de S. cerealella (Lepidoptera, Gelechiidae) mantida em repiques.

Stored grains pests ' s isoesterases: Sitotroga cereaZeZZa (Olivier, 1819), SitophiZus zeamais (Motschulsky, 1855) and TriboZium castaneum

Apresentamos uma breve revisão do problema do cruzamento preferencial e da seleção de cruzamento. O fenômeno da dependência da frequência no sucesso de cruzamento, quando dois tipos de machos estão competindo, descoberto por Petit, 1951 constitue o problema centralo da presente pesquisa.