Background-The purpose of this study was to evaluate the long-term safety of the Igaki-Tamai stent, the first-in-human fully biodegradable coronary stent made of poly-l-lactic acid. Methods and Results-Between September 1998 and April 2000, 50 patients with 63 lesions were treated electively with 84 Igaki-Tamai stents. Overall clinical follow-up (Ͼ10 years) of major adverse cardiac events and rates of scaffold thrombosis was analyzed together with the results of angiography and intravascular ultrasound. Major adverse cardiac events included all-cause death, nonfatal myocardial infarction, and target lesion revascularization/target vessel revascularization. During the overall clinical follow-up period (121Ϯ17 months), 2 patients were lost to follow-up. There were 1 cardiac death, 6 noncardiac deaths, and 4 myocardial infarctions. Survival rates free of all-cause death, cardiac death, and major adverse cardiac events at 10 years were 87%, 98%, and 50%, respectively. The cumulative rates of target lesion revascularization (target vessel revascularization) were 16% (16%) at 1 year, 18% (22%) at 5 years, and 28% (38%) at 10 years. Two definite scaffold thromboses (1 subacute, 1 very late) were recorded. The latter case was related to a sirolimus-eluting stent, which was implanted for a lesion proximal to an Igaki-Tamai stent. From the analysis of intravascular ultrasound data, the stent struts mostly disappeared within 3 years. The external elastic membrane area and stent area did not change. Conclusion-Acceptable major adverse cardiac events and scaffold thrombosis rates without stent recoil and vessel remodeling suggested the long-term safety of the Igaki-Tamai stent. (Circulation. 2012;125:2343-2352.)

Luminescent silver(I) halogenido coordination polymers [Ag 2 X 2 (PPh 3 ) 2 (bpy)] n (X = I, Br, Cl) have been prepared. The iodido and bromido complexes exhibit strong blue phosphorescence assignable to the 3 π−π*-excited-state of bpy, whereas the chlorido complex shows luminescence thermochromism due to the π−π*-state of bpy and charge transfer from the {Ag 2 Cl 2 } core to the bpy π*-orbital. Taking advantage of their structural similarities, we prepared a series of mixed-halogenido silver(I) complexes [Ag 2 (X x X′ (1−x) ) 2 (PPh 3 ) 2 (bpy)] n (X, X′ = I, Br, Cl) at varying molar fractions as solid solutions. The mixedhalogenido complexes are as strongly luminescent as their parent complexes. The detailed study of their structure and emissive properties revealed smooth energy migration between the luminescent units and modification of the luminescence properties based on the planarity of bpy.

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Thus, the determination of f/t was considered to be an effective tool for discriminating the non-prostate cancer cases from those of prostate cancer.