We investigated the clinical characteristics of healthy cats in accordance with the
target organ damage (TOD) risk category, on the basis of systolic blood pressure (SBP).
This prospective multi-center study included 137 healthy cats. Indirect blood pressure was
measured using an oscillometric technique. The median SBP in all cats was 147 mmHg
(interquartile range: 134–158). On the basis of the TOD risk category, 57.7, 19.7, 21.9,
and 0.7% of the cats were classified into categories I–IV, respectively. Age, sex, and
body weight did not affect the SBP. This study provides basic information on the
distribution of TOD risk categories in clinically healthy cats.
ABSTRACT. The feline cardiac and serum angiotensin converting enzyme (ACE) and chymase activities were determined and compered in dogs, and hamsters. In all three species, cardiac chymase activity exceeded ACE activity; however, there were some differences. In cats, left ventricular ACE and chymase activities (0.15 ± 0.01 and 0.59 ± 0.1 mU/mg-protein, respectively) were lower than in dogs (0.42 ± 0.05: p<0.01 and 2.0 ± 0.4 mU/mg-protein: p<0.01) and hamsters (0.93 ± 0.06: p<0.001 and 2.1 ± 0.2 mU/mg-protein: p<0.01); in contrast, serum ACE activities was higher in cats (12.7 ± 1.0 mU/ml) than in dogs (5.9 ± 0.6 mU/ml: p<0.001). The relative contribution of chymase (cats: 84.0 ± 5.1%, dogs: 81.4 ± 3.4%, and hamsters: 72.6 ± 5.6 %) to ANG-II formation in the heart was greater than that of ACE in these animals (cats: 10.9 ± 4.1%, dogs: 11.5 ± 3.6%, and hamsters: 17.2 ± 0.8%). These species-specific differences suggest that the efficacy of renin-angiotensin system modulating agents may differ among species. KEY WORDS: angiotensin converting enzyme inhibitor, angiotensin II type-1 receptor blocker, canine.
Chronic pressure overload on the heart of cats can activate the RA system in cardiac tissues. A local increase in angiotensin II was one of the factors that sustained myocardial remodeling.
ABSTRACT. Two kinds of FeIFN-α consisting of 166 amino acids (aa) and 171 aa were expressed in Escherichia coli, and the purified proteins were tested for antiviral activity on homologous and heterologous animal cells. Crude FeIFN induced in feline cells revealed antiviral activity on both homologous and heterologous animal cells. In contrast, both types of recombinant FeIFN-α revealed antiviral activity only on the feline cells. All of the FeIFN-α subtypes showed high activity to vesicular stomatitis virus, and the three species of feline viruses belonging to different families. KEY WORDS: animal species-specificity, expression, feline IFN-α.
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