Background:The regulation mechanism of PP5 activity remains poorly understood. Results: Ca 2ϩ /S100 proteins bind the TPR domain of PP5 and lead to activation of its enzyme activity and dissociation of the PP5-client protein interactions. Conclusion: Ca 2ϩ /S100 proteins are novel PP5 regulators. Significance: This finding provides a novel Ca 2ϩ signaling pathway via S100 proteins.
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