Febantel was developed as an oral anti-parasitic agent against monogenean Heterobothrium okamotoi for farmed tiger puŠer Takifugu rubripes. In aquaculture, febantel might be used for the sameˆsh repeatedly to obtain good anti-parasitic eŠects inˆsh farms. In this study, we investigated the safety of febantel for tiger puŠer when used repeatedly. We also investigated the impact of febantel on the marine environment. Febantel was administered toˆsh at 25 mg and 50 mg per kg of body weight forˆve days and the process was repeated after a 14-day pause. External and internal clinical signs were investigated in tiger puŠer as well as hematological parameters. During the examination period, tiger puŠers showed no decrease in appetite or changes in growth pattern compared with the control group. In addition, we observed the eŠect of febantel on diatoms (Skeletonema costatum), crustaceans (Artemia salina), andˆshes (Pagrus major) as proxies for marine organisms. The results conˆrmed no in‰uence on the tested organisms. These results suggest that febantel is safe for tiger puŠer and has no toxic eŠects in marine organisms.
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