We report a new series of hepatitis C virus NS5B RNA polymerase inhibitors containing a conformationally constrained tetracyclic scaffold. SAR studies led to the identification of 6,7-dihydro-5H-benzo[5,6][1,4]diazepino[7,1-a]indoles (19 and 20) bearing a basic pendent group with high biochemical and cellular potencies. These compounds displayed a very small shift in cellular potency when the replicon assay was performed in the presence of human serum albumin.
Although accumulating preclinical evidence indicates the involvement of androgen receptor signals in bladder cancer (BC) development, its clinical relevance remains unclear. We aimed to evaluate the predictive role of androgen deprivation therapy (ADT) in BC recurrence in prostate cancer (PC) patients.We retrospectively reviewed 20,328 patients with PC diagnosed during 1991–2013 and identified 239 (1.2%) men having primary BC. After excluding ineligible patients, 162 patients made up a final cohort.With a median follow-up of 62 months, 38 (50%) of 76 control patients without ADT experienced BC recurrence, while 19 (22%) of 86 did in ADT group. Thus, patients having received ADT for their PC showed a significantly lower risk of BC recurrence (5-year actuarial recurrence-free survival: 76% v 40%; P < 0.001) and also had a significantly smaller number of recurrence episodes (5-year cumulative recurrence: 0.44 v 1.54; P < 0.001), compared to the control patients. A multivariable analysis revealed ADT as an independent prognosticator (hazard ratio, 0.29; 95% confidence interval, 0.17–0.49) for BC recurrence.This is the first clinical study showing that ADT significantly reduces the risk of BC recurrence.
Dermatologic disorders such as atopic
dermatitis arise from genetic
and environmental causes and are complex and multifactorial in nature.
Among possible risk factors, aberrant immunological reactions are
one of the leading etiologies. Immunosuppressive agents including
topical steroids are common treatments for these disorders. Despite
their reliability in clinical settings, topical steroids display side
effects, typified by skin thinning. Accordingly, there is a need for
alternate effective and well-tolerated therapies. As part of our efforts
to investigate new immunomodulators, we have developed a series of
JAK inhibitors, which incorporate novel three-dimensional spiro motifs
and unexpectedly possess both excellent physicochemical properties
and antidermatitis efficacy in the animal models. One of these compounds,
JTE-052 (ent-60), also known as delgocitinib,
has been shown to be effective and well-tolerated in human clinical
trials and has recently been approved in Japan for the treatment of
atopic dermatitis as the first drug among Janus kinase inhibitors.
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