Aim
The number of babies born with Down syndrome has changed in recent years because of widespread availability of prenatal screening and advanced maternal age at delivery. In Japan, which has no public institutions that record data on babies born with chromosomal abnormalities (including Down syndrome), the accurate number remains unknown.
Methods
The Japan Association of Obstetricians and Gynecologists Birth Defects Monitoring Program (hereafter the JAOG Program) is the only national survey of congenital anomalies in Japan. Using data from this survey and vital statistics, we investigated the changes in the number of babies born with Down syndrome in Japan from 2006 to 2019.
Results
On performing linear regression analysis with the proportion of babies born with Down syndrome as the response variable, and the proportion of mothers giving birth at the age of 35 years or older as the explanatory variable, the regression coefficient was 0.0054 (p < 0.001). The proportion of mothers giving birth at the age of 35 years or older was useful for predicting the proportion of babies born with Down syndrome. This proportion has increased since 2006 but has remained almost unchanged since 2015. In 2019, it was 1/734.
Conclusions
This study revealed that the proportion of mothers giving birth at the age of 35 years or older strongly affected the proportion of babies born with Down syndrome. We assume that the proportion of babies is slightly affected by the increased number of pregnant women currently undergoing prenatal screening after the introduction of noninvasive prenatal genetic testing in 2013.
Lobular endocervical glandular hyperplasia (LEGH) is characterized by clinically profuse and watery vaginal discharge. In pregnancy with LEGH, with watery fluid leakage persisting throughout pregnancy, it is often difficult to visually diagnose PROM. Adding to this difficulty, auxiliary diagnostic tests might also show positive results, complicating treatment and management. K E Y W O R D S lobular endocervical glandular hyperplasia, pregnancy, premature rupture of membranes How to cite this article: Suzuki S, Sugo Y, Hiiragi K, et al. Case of suspected lobular endocervical glandular hyperplasia in a cervical cystic lesion during pregnancy.
Lobular endocervical glandular hyperplasia (LEGH) is characterized by
clinically profuse and watery vaginal discharge. In pregnancy with LEGH,
with watery fluid leakage persisting throughout pregnancy, it is often
difficult to visually diagnose PROM. Adding to this difficulty,
auxiliary diagnostic tests might also show positive results,
complicating treatment and management.
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